HO CHI MINH / SEOUL, June 8, 2026 - (ACN Newswire via SeaPRwire.com) - Global content-tech company TON Corporation (CEO Henry Kim) today announced that it will officially launch 'TonTV', its Telegram-native short-drama platform, worldwide in September 2026. TonTV lets the ~1 billion people who use Telegram each month instantly and freely watch short dramas with a single Telegram account — with no separate app install and no complicated sign-up.Short drama is one of entertainment's fastest-rising categoriesShort-form drama has moved to the center of global media consumption. Global in-app revenue for short dramas reached $2.98 billion in 2025, up 115% year over year, and in Q4 2025 short-form titles overtook long-form streaming apps in downloads for the first time (733M vs. 658M), according to Sensor Tower and Omdia. With short runtimes, high completion rates, and mobile-first immersion, the format is growing fastest among younger viewers. TonTV places dramas of around two minutes at the heart of this trend — short but intense chapters that build a "can't-stop-once-you-start" experience.The Telegram Mini App: tearing down the barrier to entryTonTV's core strength is that it runs atop Telegram, a massive global platform. Existing OTT services require a long entry sequence — app-store search → download → install → sign-up → enter payment details. TonTV removes it: open the Mini App inside Telegram → watch instantly, for free.The user reach that global OTT leaders such as Netflix and Disney+ built over years and at enormous cost is something TonTV can address from day one, across Telegram's ~1 billion monthly users. This dramatically lowers user-acquisition cost while driving early growth through natural word-of-mouth across Telegram's groups and channels.Three years of preparation, and "why we can win"TonTV did not appear overnight. Over the past three years, TON Corporation has focused on platform-technology development, global content partnerships, and a local-operations model in preparation for launch.CTO Tony cited the following reasons TonTV can be a market "game changer" rather than a late follower:Frictionless reach — among the first specialized short-drama platforms to reach Telegram's ~1 billion monthly users, free, in one clickFree entry — anyone can start at no cost, a strong advantage for early user acquisitionNetwork effects — discussion, sharing, and recommendation happen at the same moment as viewingViewer-participation rewards — enjoying content itself returns benefits and rewards, building loyaltySimultaneous global release — worldwide at once, with no region-by-region app-store approvalOn these strengths, TonTV aims to grow beyond short drama into real-time formats such as live streaming over time.A 'new stage' for producers, actors, and staff worldwideTonTV goes beyond a viewing platform to open opportunity for the global content industry. Producers can showcase work directly to a global audience; actors and staff can widen their stage across borders. For emerging teams and new actors who have struggled to get a chance at traditional broadcasters or large OTTs, TonTV offers an open stage judged on ability — creating jobs across planning, production, acting, and post-production."Global one platform, local content"TonTV places local subsidiaries in major markets — Korea, Japan, Vietnam, India, Indonesia, and the Philippines — planning and producing content suited to each region's culture on the ground. Combining a global platform's scale with local content's intimacy, TonTV aims to be a true global OTT where anyone can enjoy "stories from home." The local-subsidiary model expands content and markets quickly while keeping head-office cost low.A dual revenue model: "growth and profit together"TonTV operates a dual model: a free, ad-supported tier where all users watch at no cost, and a premium subscription for an ad-free experience. Advertiser acquisition and content production through local subsidiaries create a cycle in which ad and subscription revenue grow with the user base. Telegram's low acquisition cost and short-form's high completion rates support this model.Comment from TON Corporation CTO TonyCTO Tony said: "For the past three years we've focused everything on creating the easiest, most enjoyable way to watch drama. On Telegram — a playground of a billion people — TonTV sets a new standard for short drama anyone can enjoy free, with a single account."He added: "TonTV will create the best experience for viewers, a new stage for creators, and new jobs for the industry — and our ambition is to become the global leader in short-drama and live content."Future plansFrom its September 2026 launch, TonTV plans to rapidly expand its content lineup and service regions, broaden from short drama into real-time formats such as live streaming, and accelerate global expansion through its local subsidiaries.About TON CorporationTON Corporation is a global content-tech company headquartered in Ho Chi Minh, Vietnam. Through TonTV, its Telegram-native short-drama platform, it aims to deliver a new entertainment experience to users worldwide and open opportunity for global content creators.Media ContactBrand: TON CorporationContact: PR TeamWebsite: https://tontv.toncorp.ioTelegram: https://t.me/TontvOfficialChannel Copyright 2026 ACN Newswire via SeaPRwire.com. All rights reserved. www.acnnewswire.com

SHENZHEN, CHINA, June 8, 2026 - (ACN Newswire via SeaPRwire.com) - China Medical System Holdings Limited ("CMS" or the "Group") is pleased to announce that the preclinical results of its self-developed innovative INHBE-targeting small nucleic acid drug CMS-D008 injection ("CMS-D008"), have been presented in a poster at the American Diabetes Association (ADA) 86th Scientific Sessions (June 5-8, 2026, New Orleans, USA). As the world's largest and most authoritative annual scientific meeting in the fields of diabetes and metabolic diseases, it convened over 12,000 leading clinicians, researchers, and healthcare professionals worldwide to explore cutting-edge advances in diagnostics, therapies, and technologies.About CMS-D008CMS-D008 is a self-developed novel siRNA therapy administered by subcutaneous injection. It targets and reduces the hepatic expression of the inhibin subunit beta E (INHBE) gene and lowers the level of INHBE-encoded Activin E protein, which blocks Activin E-ALK7 signaling and reduces fat accumulation effectively. It demonstrates the potential for high-quality, long-term weight loss that boosts fat-specific loss while preserving muscle mass. Currently, the Phase I clinical trial of CMS-D008 in healthy subjects is progressing steadily. In the future, it may be developed for the treatment of abdominal obesity and related metabolic diseases.CMS-D008 has demonstrated encouraging preclinical data. The preclinical research results of CMS-D008 presented at the ADA Scientific Sessions showed that in obese animal models, CMS-D008 efficiently and sustainably suppressed INHBE expression, achieving significant weight loss and fat reduction while sparing muscle mass, with a favorable safety profile, indicating the potential for healthy weight loss. Details are as follows:Title: CMS-D008 specifically silences INHBE mRNA, delivering fat-selective weight loss in preclinical studyPresentation Number: 3079-LBPresentation format: PosterDate/Time: June 7, 2026 01:30 PM - 02:30 PM (Local Time)Location: Hall D-EResults:In a high-fat diet-induced model of humanized INHBE obese mouse (hINHBE DIO mouse), CMS-D008 significantly reduced hepatic INHBE mRNA expression and serum Activin E protein levels, leading to marked decreases in body weight, total body fat, and regional fat mass while preserving lean mass.In a model of obese cynomolgus macaque, CMS-D008 also significantly reduced hepatic INHBE mRNA expression and plasma Activin E protein levels, and effectively suppressed weight gain induced by a sustained high-fat diet.The inclusion of these findings at the ADA Scientific Sessions reflects the international academic community's interest in the scientific value and clinical potential of CMS-D008 in the field of obesity/metabolic treatment. CMS-D008 will synergize with CMS-D005, a self-developed, clinical-stage innovative drug (a GLP-1R/GCGR dual agonist), to deliver highly effective weight-loss benefits and long-term maintenance of results, providing patients with a more comprehensive and innovative treatment option.CMS is committed to in-house R&D as a core driver of its long-term growth and continues to advance innovation in cutting-edge therapeutic areas. Currently, 6 self-developed products with global rights, including CMS-D008, have entered the clinical stage, with over 20 additional self-developed projects steadily progressing in preclinical research. Looking ahead, the Group will continue to focus on unmet medical needs, efficiently advance product R&D and commercialization, and bring more comprehensive and innovative therapies to benefit broad patient population.About CMSCMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development in its advantageous specialty fields, strengthening the competitiveness of the cardiovascular-kidney-metabolic/gastroenterology/ophthalmology/skin health businesses, bringing economies of scale in specialty fields. Among them, the skin health business (Dermavon) has become a leading enterprise in its field, and is proposed to be listed independently on the SEHK. Meanwhile, CMS continuously promotes the operation and development of its integrated R&D, manufacturing and commercialization chain in Southeast Asia and the Middle East, capturing growth opportunities in emerging markets to support the high-quality and sustainable development of the Group.CMS Disclaimer and Forward-Looking StatementsThis press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.Media ContactBrand: China Medical System Holdings Ltd.Contact: CMS Investor RelationsEmail: ir@cms.net.cnWebsite: https://web.cms.net.cn/en/home/ Copyright 2026 ACN Newswire via SeaPRwire.com. All rights reserved. www.acnnewswire.com

香港, 2026年6月8日 - (亚太商讯 via SeaPRwire.com) - 云顶新耀（HKEX 1952.HK）宣布与箕星药业（以下简称"箕星"）达成资产收购协议 (The Asset Purchase Agreement)，获得LNZ100（1.44% 醋克利定，美国商品名VIZZ）在大中华区（包含中国大陆，中国香港，中国澳门和中国台湾地区）的开发、生产与商业化权益。根据协议，云顶新耀将向箕星药业支付首付款以及开发里程碑付款。作为本协议的一部分，云顶新耀将获得箕星药业于2022年4月签订的许可协议及相关附属协议项下的权利、权益、主张、职责、义务及责任。此次交易将进一步丰富公司的创新产品组合，强化云顶新耀在眼科领域的布局，并提升战略协同效应。LNZ100是一款每日滴用一次、用于治疗老视的滴眼液，其主要成分醋克利定是一种小分子毒蕈碱型乙酰胆碱能受体（mAChR）激动剂，可引起瞳孔缩小，从而产生改善近视力的针孔效应。研究表明醋克利定的作用机制非常理想，基于其独特的高选择性瞳孔作用机制，既可以产生理想的缩瞳效应，又避免了近视漂移，因此具有针对最广泛患者群体的应用潜力。据公开资料显示，LNZ100已于2025年7月在美国获批，并于同年10月实现商业化上市；在中国，LNZ100已于2025年9月递交新药上市申请，预计2027年第一季度获批，有望填补国内治疗空白，成为针对老视的潜在同类最佳无创治疗方案。云顶新耀董事会主席吴以芳表示："此次收购LNZ100是公司持续深化眼科领域战略布局的重要一步。LNZ100作为一款兼具差异化优势和广阔市场前景的创新产品，在老视治疗领域具有明确的临床价值与应用潜力。随着人口结构变化，老视患者群体不断扩大，而无创治疗仍存在显著未满足的需求。LNZ100有望为老视患者提供全新的治疗选择，并进一步丰富眼科创新治疗方案。 LNZ100已在美国获批上市，目前正在中国加快推进新药上市审评进程。未来，我们将加快LNZ100的开发和上市，推动这一创新疗法尽早惠及更多老视患者。"箕星药业董事会执行董事兼首席执行官牟艳萍表示："我们相信云顶新耀凭借其卓越的商业化能力，将加速推进LNZ100的市场可及性，惠及更多中国老视患者。此次交易之后，箕星的产品管线全部聚焦心血管及代谢疾病治疗领域，该交易所获资金将助力箕星加速推进创新管线的全球临床开发。"老视，俗称"老花眼"，是指随着年龄增长，看近处物体逐渐模糊的生理现象。其原因在于眼部晶状体逐渐硬化、弹性减弱，导致调节功能下降，无法将近处物体的像聚焦在视网膜上，从而导致近视力下降。老视是随年龄增长常见的生理变化，研究显示，中国人群老视的平均发病年龄约为38岁，而到52岁时，发病率接近100%。目前，老视的治疗手段非常有限。佩戴眼镜需要频繁摘戴，给工作和生活带来诸多不便；手术作为侵入性、不可逆的有创操作，接受程度也十分有限。在非侵入性、安全有效且可逆的药物治疗方面，老视领域存在巨大的未满足医疗需求。此次LNZ100获中国NMPA新药上市申请受理是基于中国III期临床研究所取得的数据结果。该研究是一项多中心、随机、双盲、安慰剂对照的3期临床试验，由4周疗效试验和总计6个月的安全性试验组成，共招募了300名受试者，旨在观察LNZ100改善中国老视人群近视力并确证其疗效与安全性。研究结果显示，LNZ100达到了主要终点和关键次要终点，最佳远矫正下的近视力 （BCDVA）有三行或更佳的显著改善，并保持其最佳远视力（即视力下降不可超过5个字母）。研究结果还显示（所有p值均小于0.0001），LNZ100起效迅速，分别有84%和69%的受试者在用药后30分钟即获得两行及三行字母或更佳的近视力改善。且LNZ100药效持久，分别有61%和30%的受试者在用药后10 小时仍保持两行及三行字母或更佳的近视力改善。此外，LNZ100也具备出色的安全性，耐受性良好，在试验中没有发现与治疗相关的严重不良事件。近年来，云顶新耀已建立经过验证的以"科学及商业洞察驱动的准入、医学、市场、销售一体化协同（A2MS）"为核心的创新药商业化运营平台。随着多个创新产品陆续进入商业化阶段，公司商业化平台的规模效应和协同效应正持续释放。在此背景下，引入具备明确临床价值和市场潜力的后期资产，成为公司丰富产品组合、拓展增长空间的重要举措。此次获得LNZ100大中华区权益，将进一步强化云顶新耀眼科领域布局，并与现有商业化体系形成协同，持续提升创新资产的商业化价值。 Copyright 2026 亚太商讯 via SeaPRwire.com. All rights reserved. www.acnnewswire.com

HONG KONG, Jun 8, 2026 - (ACN Newswire via SeaPRwire.com) - Everest Medicines (HKEX 1952.HK) announced that it has entered into an Asset Purchase Agreement with Corxel Pharmaceuticals (“CORXEL”). Under the agreement, Everest has acquired the rights to develop, manufacture, and commercialize LNZ100 (1.44% aceclidine, U.S. brand name VIZZ) in Greater China, including Chinese mainland, Hong Kong SAR, Macao SAR, and Taiwan region. Everest will pay an upfront payment and potential development milestone payments. As part of this agreement, Everest will be assigned and transferred the rights and obligations under the LENZ License Agreement entered into by CORXEL in April 2022 and certain related ancillary agreements. This transaction is expected to further expand the Company’s innovative product portfolio, strengthen its presence in ophthalmology, and enhance overall strategic synergies across its business.LNZ100 is a once-daily prescription eye drop indicated for the treatment of presbyopia. Its active ingredient, aceclidine, is a small molecule acetylcholine receptor agonist that causes pupil contraction, or miosis, creating a pinhole effect that improves near vision. Studies have shown that aceclidine's mechanism of action (MOA) is well positioned to create a pinhole pupil effect while avoiding the impairment of distance vision called myopic shift. Aceclidine's unique pupil selective MOA, in which miosis is decoupled from myopic shift, is expected to allow it to target a broad patient population.According to publicly available information, LNZ100 received approval in the United States in July 2025 and was commercially launched in October of the same year. In China, the New Drug Application (NDA) for LNZ100 was submitted in September 2025, with approval expected in the first quarter of 2027. The therapy has the potential to address a significant unmet medical need in China and position itself as a best-in-class, non-invasive treatment option for presbyopia.“The acquisition of LNZ100 represents an important step in advancing Everest’s strategic focus in ophthalmology. LNZ100 is a differentiated asset with meaningful clinical value and strong commercial potential in the treatment of presbyopia,” said Yifang Wu, Chairman of the Board of Everest Medicines. “As the presbyopia patient population continues to grow, significant unmet needs remain in non-invasive treatment options. We believe LNZ100 has the potential to offer patients a novel, non-invasive therapeutic option and to further broaden the landscape of innovative ophthalmic treatments. The product has already been approved in the United States and is currently under regulatory review in China. We will continue to advance its development and commercialization to make this therapy accessible to presbyopia patients.”Ms. Sandy Mou, Board Executive Director and Chief Executive Officer of CORXEL, said: “We are confident that Everest Medicines’ strong commercialization capabilities will accelerate LNZ100’s market access and bring this innovative treatment to more presbyopia patients in China. Following this transaction, CORXEL’s pipeline will be entirely focused on cardiometabolic therapies. The proceeds from the transaction will enable CORXEL to accelerate the global clinical development of its innovative cardiometabolic pipeline.”Presbyopia is a physiological phenomenon associated with aging that results in a progressively worsening ability to see nearby objects clearly. It is caused by the gradual hardening of the lens. This results in a decline of the eye’s adjustment function, and the inability to focus the image of nearby objects on the retina, leading to a decline in near vision. Studies have shown that the onset of presbyopia typically occurs around the age of 38, reaching a prevalence rate of nearly 100 percent at the age of 52 in China. Currently, the treatment options for presbyopia are very limited. Wearing glasses requires frequent removal and insertion, causing many inconveniences in work and life. Surgery, as an irreversible and invasive operation, has very limited acceptance. There are no approved drugs for the treatment of presbyopia in China and the medical need for non-invasive, safe, efficient and reversible treatments for presbyopia remains unsolved.The NDA acceptance of LNZ100 by the National Medical Products Administration (NMPA) of the People’s Republic of China is based on the data from China Phase 3 Trial. The study was a Phase 3, multicenter, randomized, double-blind, vehicle-controlled study, including a 4-week efficacy study followed by a 6-month extension safety study, designed to evaluate the efficacy and safety of LNZ100 (an aceclidine-based ophthalmic solution) in participants with presbyopia. The objectives were to assess the potential of LNZ100 to improve near vision among Chinese presbyopia patients and to evaluate the efficacy and safety profiles. The trial has enrolled 300 participants.The results showed that LNZ100 achieved the primary endpoint and key secondary endpoints, with statistically significant three-lines or greater improvement in Best Corrected Distance Visual Acuity (BCDVA) at near, and maintaining their optimal distance visual acuity (i.e., not losing 5 or more letters). Results also showed (all p

OTTAWA, ON, June 8, 2026 - (ACN Newswire via SeaPRwire.com) - Focus Graphite Inc. (TSXV: FMS) (OTCQB: FCSMF) (FSE: FKC0) ("Focus" or the "Company") a Canadian developer of high-grade flake graphite deposits and advanced graphite materials for battery, defence, and industrial applications, is pleased to announce the completion of the. Air Quality Assessment ("AQA" or the "Study") for its 100%-owned Lac Knife Graphite Project (the "Project") located in northeastern Quebec.The Study was completed by WSP Canada Inc. ("WSP"), one of the world's leading engineering and environmental consulting firms, under the supervision and management of IOS Geosciences Inc. ("IOS"), as part of the environmental studies supporting the advancement of Lac Knife toward future permitting and development.The AQA evaluated emissions associated with the proposed open pit mine, processing facility, tailings storage facility, stockpiles, haul roads, crushing operations, and supporting infrastructure under conservative maximum operating scenarios. Atmospheric dispersion modelling using Aeromod software, was completed in accordance with the requirements of Quebec's Reglement sur l'assainissement de l'atmosphere ("RAA") and applicable guidance from the Ministere de l'Environnement, de la Lutte contre les changements climatiques, de la Faune et des Parcs ("MELCCFP").According to WSP's conclusions, the modelling results demonstrate that predicted contaminant concentrations remain in compliance with applicable Quebec ambient air quality standards and criteria under the assessed operating conditions. WSP further concluded that all evaluated contaminants met applicable regulatory thresholds. The Study also noted that prevailing winds are predominantly directed toward the south-southeast, away from nearby public infrastructure, residences, and seasonal fishing cabins."Environmental permitting is one of the most important value-creation stages in the development of any critical mineral project," said Dean Hanisch, CEO of Focus Graphite. "The completion of the Air Quality Assessment represents another key component of the broader environmental review process and brings us closer to completing the environmental studies required to support future permitting activities. As these workstreams are completed, Lac Knife continues to become increasingly de-risked from both a technical and environmental perspective while strengthening its position as a strategic North American graphite asset."The Study evaluated a broad range of potential emissions, including particulate matter, nitrogen oxides, sulphur dioxide, carbon monoxide, crystalline silica, and various metals, using a detailed atmospheric dispersion model of the Project area and surrounding receptors based on five years of regional meteorological data.Advancing Toward Environmental Assessment CompletionThe AQA forms part of the broader environmental and permitting work program being advanced at Lac Knife and represents another important milestone toward completion of the environmental and social impact assessment ("ESIA") process. With this Study now complete, the Company is advancing the remaining key environmental workstreams, including the hydrogeological assessment and dam breach analysis, which are expected to further support permitting activities and future project development.The completion of the AQA builds on a series of technical, environmental and infrastructure achievements that continue to de-risk the Project and strengthen Lac Knife's position as a strategically important North American graphite asset. As demand for secure and reliable graphite supply continues to grow, Focus remains focused on advancing the Project through the key milestones required for future development.Qualified PersonThe technical content disclosed in this news release was reviewed and approved by Rejean Girard, P.Geo. (QC), President of IOS Geosciences Inc., a consultant to the Company, and a qualified person as defined under National Instrument NI-43-101.About Focus Graphite Advanced Materials Inc. Focus Graphite Advanced Materials is redefining the future of critical minerals with two 100% owned world-class graphite projects and cutting-edge battery technology. Our flagship Lac Knife project stands as one of the most advanced high-purity graphite deposits in North America, with a fully completed feasibility study. Lac Knife is set to become a key supplier for the battery, defense, and advanced materials industries.Our Lac Tetepisca project further strengthens our portfolio, with the potential to be one of the largest and highest-purity and grade graphite deposits in North America. At Focus, we go beyond mining - we are pioneering environmentally sustainable processing solutions and innovative battery technologies, including our patent-pending silicon-enhanced spheroidized graphite, designed to enhance battery performance and efficiency.Our commitment to innovation ensures a chemical-free, eco-friendly supply chain from mine to market. Collaboration is at the core of our vision. We actively partner with industry leaders, research institutions, and government agencies to accelerate the commercialization of next-generation graphite materials. As a North American company, we are dedicated to securing a resilient, locally sourced supply of critical minerals — reducing dependence on foreign-controlled markets and driving the transition to a sustainable future.For more information on Focus Graphite Inc., please visit http://www.focusgraphite.com.LinkedIn: https://www.linkedin.com/company/focus-graphite/X: https://x.com/focusgraphiteInvestors Contact: Dean Hanisch CEO, Focus Graphite Inc. dhanisch@focusgraphite.com +1 (613) 612-6060Jason LatkowcerVP Corporate Developmentjlatkowcer@focusgraphite.comCautionary Note Regarding Forward-Looking StatementsCertain statements contained in this press release constitute forward-looking information. These statements relate to future events or future performance. The use of any of the words "could," "intend," "expect," "believe," "will," "projected," "estimated," and similar expressions, as well as statements relating to matters that are not historical facts, are intended to identify forward-looking information and are based on the Company's current beliefs or assumptions as to the outcome and timing of such future events.In particular, this press release contains forward-looking information regarding, among other things: the advancement of the Lac Knife Graphite Project toward permitting readiness and future development; the completion and timing of the remaining environmental studies required to support the environmental and social impact assessment ("ESIA") process, including the hydrogeological assessment and dam breach analysis; the anticipated completion of environmental baseline, technical and permitting workstreams; the Company's ability to obtain required permits, approvals and authorizations; the anticipated benefits of completed environmental and technical studies, including the Air Quality Assessment; the timing and completion of future project milestones; the future development, construction and operation of the Lac Knife Project; the role of the Project in supporting North American and allied critical mineral supply chains; and the Company's long-term development strategy.Forward-looking statements are subject to known and unknown risks, uncertainties, and other factors that may cause actual results, performance, or achievements to differ materially from those expressed or implied by such statements. These risks and uncertainties include, but are not limited to, risks related to market conditions, regulatory approvals, changes in economic conditions, the ability to raise sufficient funds on acceptable terms or at all, operational risks associated with mineral exploration and development, and other risks detailed from time to time in the Company's public disclosure documents available under its profile on SEDAR+.The forward-looking information contained in this release is made as of the date hereof, and the Company is not obligated to update or revise any forward-looking information, whether as a result of new information, future events, or otherwise, except as required by applicable securities laws. Because of the risks, uncertainties, and assumptions contained herein, investors should not place undue reliance on forward-looking information.Neither TSX Venture Exchange nor its Regulation Services accepts responsibility for the adequacy or accuracy of this release.To view the source version of this press release, please visit https://www.newsfilecorp.com/release/300471 Copyright 2026 ACN Newswire via SeaPRwire.com. All rights reserved. www.acnnewswire.com

深圳, 2026年6月8日 - (亚太商讯 via SeaPRwire.com) - 康哲药业控股有限公司（867.HK/8A8.SG）（“康哲药业”）欣然宣布，其自主研发的创新药INHBE小核酸药物CMS-D008注射液（“CMS-D008”）的临床前结果在第86届美国糖尿病协会（ADA）大会（2026年6月5-8日，美国新奥尔良）以壁报形式发布。ADA大会作为全球糖尿病及代谢疾病领域规模最大、最具权威影响力的年度学术风向标，此次汇聚了来自世界各地的超过12,000名顶尖临床专家、科研学者及一线医疗工作者，共同探讨与见证前沿诊疗成果与技术创新突破。关于CMS-D008CMS-D008是康哲药业自主研发的一款皮下注射的siRNA药物，靶向抑制肝脏的抑制素亚基βE（INHBE）基因表达，下调INHBE编码蛋白激活素E（Activin E）水平，从而降低脂肪代谢通路Activin E-ALK7的活化，有效减少脂质堆积，显示出减脂不减肌、长期高质量减重的潜力。目前，CMS-D008的健康受试者I期临床试验正在稳步推进中；未来拟开发治疗腹型肥胖以及相关代谢性疾病。CMS-D008展现出令人鼓舞的非临床数据。本次在ADA大会发表CMS-D008的临床前研究结果显示，在肥胖动物模型中，CMS-D008可高效持续抑制INHBE表达，在不影响肌肉的情况下，获得明显的减重减脂效果，且安全性良好，有望实现健康减重。具体信息如下：标题：CMS-D008可特异性抑制INHBE mRNA，并在临床前研究中实现了针对脂肪的减重效果摘要号：3079-LB展示形式：壁报时间：2026年6月7日01:30 PM - 02:30 PM（当地时间）地点：Hall D-E研究结果：- 在高脂饮食诱导的人源化INHBE肥胖小鼠（hINHBE DIO 小鼠）模型中，CMS-D008可显著降低肝脏中INHBE mRNA及血清中靶蛋白Activin E的水平，进而显著降低小鼠的体重、体脂、不同部位脂肪，且不影响小鼠的肌肉含量。- 在肥胖食蟹猴模型中，CMS-D008也可显著降低肝脏中INHBE mRNA及血浆中靶蛋白Activin E的表达，并显著抑制因持续摄入高脂饮食而引起的体重上升。此次研究成果入选ADA大会，体现了CMS-D008在肥胖/代谢治疗领域的科学价值与临床潜力受到国际学术界的关注。CMS-D008亦可与康哲药业临床开发阶段的自研创新药CMS-D005（GLP-1R/GCGR双重激动剂）形成协同，有望实现高效的减重获益与长期的成果维持，为患者提供更全面的治疗方案。康哲药业将自主研发作为长期发展的核心驱动力，持续深耕前沿创新领域。目前已有包括CMS-D008在内的6款拥有全球权益的自研产品进入临床阶段，另有逾20项自研项目稳步推进临床前研究。未来，康哲药业将继续聚焦未被满足的临床需求，高效推动产品的研发与商业化进程，以更全面、创新的疗法惠及广大患者。关于康哲药业康哲药业是一家链接医药创新与商业化，把控产品全生命周期管理的开放式平台型企业，致力于提供有竞争力的产品和服务，满足尚未满足的医疗需求。康哲药业专注于全球首创（FIC）及同类最优（BIC）的创新产品，并高效推进创新产品临床研究开发和商业化进程，赋能科研成果向诊疗实践的持续转化，造福患者。康哲药业聚焦专科领域，拥有被验证的商业化能力，广泛的渠道覆盖和多疾病领域专家资源，核心在售产品已获领先的学术与市场地位。康哲药业围绕优势专科领域不断纵深发展，以巩固心肾代谢/消化/眼科/皮肤健康业务竞争力，带来专科规模效率，其中皮肤健康业务（德镁医药）已成为其细分领域的龙头企业，并拟于联交所独立上市。同时，康哲药业持续推动研产销全产业链在东南亚及中东区域运营发展，以获取新兴市场的增量，助力集团实现高质量可持续发展。康哲药业免责与前瞻性声明本新闻无意向您做任何产品的推广，非广告用途。本新闻不对任何药品和医疗器械和/或适应症作推荐。若您想了解具体疾病诊疗信息，请遵从医生或其他医疗卫生专业人士的意见或指导。医疗卫生专业人士作出的任何与治疗有关的决定应根据患者的具体情况并遵照药品说明书。由康哲药业编制的此新闻不构成购买或认购任何证券的任何要约或邀请，不形成任何合约或任何其他约束性承诺的依据或加以依赖。本新闻由康哲药业根据其认为可靠之资料及数据编制，但康哲药业并无进行任何说明或保证、明述或暗示，或其他表述，对本新闻内容的真实性、准确性、完整性、公平性及合理性不应加以依赖。本新闻中讨论的若干事宜可能包含涉及康哲药业的市场机会及业务前景的陈述，该等陈述分别或统称为前瞻性声明。该等前瞻性声明并非对未来表现的保证，存在已知及未知的风险、不明朗性及难以预知的假设。康哲药业并不采纳本新闻包含的第三方所做的任何前瞻性声明及预测，康哲药业对该等第三方声明及预测不承担责任。 Copyright 2026 亚太商讯 via SeaPRwire.com. All rights reserved. www.acnnewswire.com