“LEQEMBI(R)” (lecanemab) IV Maintenance Dosing for the Treatment of Early Alzheimer’s Disease Approved in the United Kingdom JCN Newswire

“LEQEMBI(R)” (lecanemab) IV Maintenance Dosing for the Treatment of Early Alzheimer’s Disease Approved in the United Kingdom

TOKYO and CAMBRIDGE, Mass., Nov 14, 2025 - (JCN Newswire via SeaPRwire.com) - Eisai Co., Ltd. (Headquarters: Tokyo, CEO: Haruo Naito, “Eisai”) and Biogen Inc. (Nasdaq: BIIB, Corporate headquarters: Cambridge, Massachusetts, CEO: Christopher A. Viehbacher, “Biogen”) announced today that humanized anti- soluble aggregated amyloid-beta (Aβ) monoclonal antibody “LEQEMBI®” (generic name: lecanemab) has been approved for once every four weeks intravenous (IV) maintenance dosing by the Medicines and Healthcare products Regulatory Agency (MHRA) in the United Kingdom.In August 2024, LEQEMBI was approved for the treatment of mild cognitive impairment (MCI) and mild dementia due to Alzheimer’s disease (AD) in adult patients that are apolipoprotein E ε4 (ApoE ε4)* heterozygotes or non-carriers in the United Kingdom. With this latest approval for IV maintenance dosing, after 18 months of a dosing regimen of 10 mg/kg once every two weeks patients may be transitioned to the maintenance dosing regimen of 10 mg/kg once every four weeks, or the regimen of 10 mg/kg once every two weeks may be continued.AD is a progressive, relentless disease characterized by formation of protein deposits known as plaques made of amyloid-beta aggregates and neurofibrillary tangles made of tau protein in the brains of people living with AD. It is caused by a continuous underlying neurotoxic process that begins before amyloid plaque accumulation and continues after plaque removal.1,2 The data show that amyloid-beta protofibrils and tau tangles play roles in the neurodegeneration process,2,3 and only LEQEMBI fights AD in two ways – targeting both amyloid plaque and protofibrils**, which can impact tau downstream.Due to the reaccumulation of AD biomarkers and return to placebo rate of decline after therapy is stopped,3-5 continuing maintenance treatment after the initial 18-month therapy is essential to slow the progression of AD and extend the therapeutic benefits, helping patients maintain who they are for longer.In the United Kingdom, it is estimated that 982,000 people are living with dementia,6 and AD is the cause in 60-70% of people with dementia.7 These numbers are expected to rise, as the population ages.6, 7Eisai serves as the lead for lecanemab’s development and regulatory submissions globally with Eisai and Biogen co-commercializing and co-promoting the product and Eisai having final decision-making authority.* Apolipoprotein E is a protein involved in the metabolism of lipid in humans. It is implicated in AD. People with only one (heterozygous) or no copy (non-carriers) of the ApoE ε4 gene are less likely to experience ARIA than people with two ApoE ε4 copies (homozygous).8** Protofibrils are thought to be the most toxic Aβ species that contribute to brain damage in AD and play a major role in the cognitive decline of this progressive and devastating disease. Protofibrils can cause neuronal and synaptic damage in the brain, which can subsequently adversely affect cognitive function through multiple mechanisms.3 The mechanism by which this occurs has been reported not only by increasing the formation of insoluble Aβ plaques, but also by directly damaging signaling between neurons and other cells. It is believed that reducing protofibrils may reduce neuronal damage and cognitive impairment, potentially slowing the progression of AD.4MEDIA CONTACTSEisaiEisai Co., Ltd.Public Relations DepartmentTEL: +81 (0)3-3817-5120Eisai Inc. (U.S.)Libby Holman+1-201-753-1945Libby_Holman@eisai.comBiogen Inc.Madeleine Shin+ 1-781-464-3260public.affairs@biogen.comINVESTOR CONTACTSEisai Co., Ltd.Investor Relations DepartmentTEL: +81 (0)3-3817-5122Biogen Inc.Tim Power+ 1-781-464-2442IR@biogen.comAbout LEQEMBI (generic name: lecanemab)Lecanemab is the result of a strategic research alliance between Eisai and BioArctic. It is a humanized immunoglobulin gamma (IgG1) monoclonal antibody directed against aggregated soluble (protofibril) and insoluble forms of amyloid-beta (Aβ).Lecanemab has been approved in 51 countries and is under regulatory review in 9 countries. Following the initial phase with treatment every two weeks for 18 months, intravenous (IV) maintenance dosing with treatment every four weeks was approved in the United Kingdom, the U.S, China and others, and applications have been filed in 4 countries and regions.LEQEMBI's approvals in these countries were based on Phase 3 data from Eisai's, global Clarity AD clinical trial, in which it met its primary endpoint and all key secondary endpoints with statistically significant results. The primary endpoint was the global cognitive and functional scale, Clinical Dementia Rating Sum of Boxes (CDR-SB).1 The U.S. FDA approved Eisai’s Biologics License Application (BLA) for subcutaneous maintenance dosing with LEQEMBI IQLIK in August 2025. In September 2025, the rolling sBLA application to the U.S. FDA for the subcutaneous initiation dosing with LEQEMBI IQLIK was also initiated.Since July 2020 the Phase 3 clinical study (AHEAD 3-45) for individuals with preclinical AD, meaning they are clinically normal and have intermediate or elevated levels of amyloid in their brains, is ongoing. AHEAD 3-45 is conducted as a public-private partnership between the Alzheimer's Clinical Trial Consortium that provides the infrastructure for academic clinical trials in AD and related dementias in the U.S, funded by the National Institute on Aging, part of the National Institutes of Health, Eisai and Biogen. Since January 2022, the Tau NexGen clinical study for Dominantly Inherited AD (DIAD), that is conducted by Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU), led by Washington University School of Medicine in St. Louis, is ongoing and includes lecanemab as the backbone anti-amyloid therapy.For more details, please visit: https://www.eisai.com/news/2025/pdf/enews202579pdf.pdf Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
NEC Advances Research Information Infrastructure for Open Science JCN Newswire

NEC Advances Research Information Infrastructure for Open Science

TOKYO, Japan, Nov 17, 2025 – NEC Corporation (NEC; TSE: 6701) has launched a new suite of solutions designed for research institutions, such as universities, to promote open science.By offering a comprehensive set of solutions that enhance competitiveness in research and development and ensure the transparency of research outcomes, NEC aims to contribute to the efficient and effective establishment of research information infrastructure (RII).In recent years, the trend towards open science, which involves sharing research data across society, has accelerated. As a result, there is a growing demand from research institutions for improved management, storage, and utilization of research data.Furthermore, as part of enhancing international research competitiveness and ensuring the transparency of research outcomes, there is a rising demand for stronger governance, including requirements for the proper management and storage of research data.In response, NEC is launching a suite of solutions that enables the efficient and effective creation of RII, from introduction to operation. Value Provided to Customers through Advanced Research Information InfrastructureContributing to Enhanced Collaboration with Research Institutions and Accelerated real world Implementation through Advanced Research Information InfrastructureNEC provides a suite of solutions for the appropriate and efficient utilization of research data throughout the entire lifecycle of research, including data generation, analysis, aggregation, management, publication, and utilization. These solutions contribute to fostering collaboration with universities and research institutions and promoting the real world implementation of research findings.Overall Concept of Research Information Infrastructure (RII)NEC offers the following solutions:- NEC Ultra-high-speed Data Transfer System This system enables efficient aggregation and sharing of large-scale research data generated by various experimental and measurement facilities and high-performance computing (HPC) simulations. It maximizes network bandwidth and achieves high-speed disk-to-disk data transfer. This solution is effective in scenarios such as sharing large-scale experimental research data, utilizing large-scale data aggregation platforms, and implementing business continuity plans (BCP).Usage Scenario of NEC Ultra-high-speed Data Transfer System- NEC Data Provenance System for HPC (*1) This system automatically collects and allows reference to provenance information, such as input/output files and program execution details, in HPC simulations. It allows easy reference to provenance information without special processing during simulation execution, and this information can also be shared with others. This solution is effective in improving research efficiency by clarifying simulation reproduction procedures and simplifying the identification of data to be saved. It is also valuable for presenting data as evidence for papers and for use in collaborative research.Usage Scenario of NEC Data Provenance System for HPC* Data Catalog and Portal System for Promoting Research Data Utilization, Including AI-driven Approaches Serving as a portal for RII, this system promotes data aggregation and facilitates data utilization by users and administrators.* Resource Pooling and Remote Resource Utilization System utilizing NEC's proprietary ExpEther (Express Ether) Technology for Reliable, Low-Latency Transmission of IT Device Signals (*2) This system enables the utilization of remote computing resources, even for sensitive data that cannot be taken off-site.NEC provides these solutions as an integrated system tailored to customer environments.Comments on this announcement are as follows:The University of Osaka D3 Center has launched operations of the Data Provenance System for HPC via the "Osaka University Compute and sTOrage Platform Urging open Science" (OCTOPUS), a computational and data platform promoting open science introduced in September 2025. Every day, supercomputers at computing centers analyze and generate vast amounts of academic data. One of the challenges facing platform providers offering computational infrastructure for academic research is how to ensure the fairness of calculations performed on computers. Since the research process and results are often recorded and managed manually by researchers, I believe that realizing transparency in the research process and implementing an efficient audit trail management system through the automation of recording of computational provenance will significantly contribute to promoting open science.- Susumu Date, Professor, Advanced High-Performance Computing Infrastructure Systems Research Division, D3 Center, The University of OsakaThe Square Kilometre Array Observatory (SKAO) is a project aimed at constructing the world’s largest radio telescope. This initiative will require transferring unprecedented volumes of observational data between data centers worldwide, which presents a significant challenge in implementing high-speed, reliable data transfer infrastructure. The ultra-high-speed data transfer system provided by NEC enables 100 Gbps-class communication between storage located in remote areas, and we are currently conducting verification testing to prepare for its introduction as an effective solution to this challenge.- Takuya Akahori, Project Researcher, Lead of the SKA1 Promotion Group, Mizusawa VLBI Observatory, National Astronomical Observatory of Japan (NAOJ), National Institutes of Natural Sciences (NINS)Event InformationExhibition booth at SC25, the world's largest international conference for HPC and AI. Date: November 16-21, 2025, Location: St. Louis, USA. Details here: https://sc25.supercomputing.org/(*1): Data Provenance System for HPC has been pre-introduced at The University of Osaka The University of Osaka D3 Center Commences Operation of New Computing and Data Infrastructure Built by NEChttps://www.nec.com/en/press/202509/global_20250912_01.html(*2: Demonstrations on the utilization of ExpEther have begun at The University of Osaka. The University of Osaka D3 Center and NEC Demonstrate Wide-Area Distributed Campus AI Processing Platformhttps://www.nec.com/en/press/202511/global_20251113_01.htmlAbout NEC CorporationNEC Corporation has established itself as a leader in the integration of IT and network technologies while promoting the brand statement of "Orchestrating a brighter world." NEC enables businesses and communities to adapt to rapid changes taking place in both society and the market as it provides for the social values of safety, security, fairness and efficiency to promote a more sustainable world where everyone has the chance to reach their full potential. For more information, visit NEC at https://www.nec.com. Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
Mitsubishi Shipbuilding Delivers Large Car Ferry KEYAKI to Shin Nihonkai Ferry and Japan Railway Construction, Transport and Technology Agency JCN Newswire

Mitsubishi Shipbuilding Delivers Large Car Ferry KEYAKI to Shin Nihonkai Ferry and Japan Railway Construction, Transport and Technology Agency

The KEYAKITOKYO, Nov 17, 2025 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Shipbuilding Co., Ltd., a part of Mitsubishi Heavy Industries (MHI) Group, delivered the large car ferry KEYAKI, produced for Shin Nihonkai Ferry Co., Ltd. and Japan Railway Construction, Transport and Technology Agency (JRTT), at the Enoura Plant of MHI's Shimonoseki Shipyard & Machinery Works in Yamaguchi Prefecture on the 11th. The new ferry will serve on a shipping route between the cities of Otaru in Hokkaido and Maizuru in Kyoto Prefecture from the 14th.The KEYAKI is the first ferry in Japan to adopt the latest energy-saving hull form, including a KATANA BOW and buttock-flow stern hull(Note1) with ducktail(Note2). Propulsion resistance is suppressed by an energy-saving roll-damping system combining an anti-rolling tank(Note3) and fin stabilizers(Note4). Together these innovations enable a 5% savings in energy compared to earlier vessels.The interior of the ferry features open spaces including a three-story atrium at the entrance, elevators with clear walls and doors, and a forward salon with a two-story atrium. There is an open-air bath on the top deck and a multipurpose room for enjoying a variety of activities. A variety of cabins are available to provide maritime travel experiences that meet various needs.Going forward, Mitsubishi Shipbuilding will continue to contribute to active use of sea transport and environmental protection, resolving diverse issues together with its business partners through construction of ferries that provide stable sea transport together with outstanding energy and environmental performance.1A hull design that reduces water resistance by optimizing the shape of the stern.2A hull form with the stern protruding like a duck's tail.3An anti-rolling tank contains water that shifts laterally within a ship's beam. When a vessel rolls, the tank water moves in the direction opposite to the rolling, easing the rolling effect.4Fin stabilizers are another device that reduces ship rolling. Attached to both sides of the hull, these movable fins generate lifting power in the water in the direction opposite to the rolling.Main Specifications of the KEYAKIShip typePassenger-carrying car ferryLOA199mBeam25.5mGross tonnage14,157tService speed28.3 knotsPassengers286CapacityApprox. 150 trucks and 30 passenger cars About MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
Hitachi Employee Receives the “Chop Wood Carry Water Award” from the Global OSS Organization CNCF for Leading the Establishment of Official Community in Japan JCN Newswire

Hitachi Employee Receives the “Chop Wood Carry Water Award” from the Global OSS Organization CNCF for Leading the Establishment of Official Community in Japan

TOKYO, Nov 14, 2025 - (JCN Newswire via SeaPRwire.com) - Hitachi, Ltd. ("Hitachi") today announced that Head of Hitachi OSPO (Open Source Program Office)*1 Yuichi Nakamura has received the "Chop Wood Carry Water Award" from the Cloud Native Computing Foundation (CNCF)*2, the world's largest organization promoting innovation in cloud native and AI technologies. This award recognizes members who have contributed to various open source software (OSS) development projects and dedicated themselves to invigorating and supporting the communities behind them. This year, six recipients were selected from over 720 organizations affiliated with the CNCF.This award recognizes Nakamura’s dedication to establishing and operating Japan’s first official community, Cloud Native Community Japan (CNCJ)*3, in a way that transcends corporate boundaries. He was also highly recognized for his efforts in bringing the CNCF global event "KubeCon + CloudNativeCon Japan 2025" to Japan for the first time, together with CNCJ members, and successfully co-hosting the FinOps Foundation event. These initiatives have helped create opportunities for OSS engineers in Japanese companies to thrive and contribute to the advancement of a digital society centered on AI.Hitachi has long recognized the value of OSS as essential to the development of a digital society and has actively promoted its use in both IT and OT domains. Nakamura has driven the business application of OSS at Hitachi while also feeding back that expertise to multiple OSS communities. As a leading figure in Japan's OSS community, he has achieved numerous accomplishments. Moving forward, Hitachi will continue to work with customers, partners, and OSS communities to build an AI ecosystem that addresses social challenges and contributes to the realization of a sustainable society.(*1) News Release "Established the Open Source Program Office (OSPO) to Globally Lead the Strategic Utilization of OSS" (November 8, 2024)https://www.hitachi.com/New/cnews/month/2024/11/241108.html(*2) A non-profit organization under The Linux Foundation that globally leads the development and adoption of cloud native technologies such as containers and microservices(*3) News Release "Participating in the Establishment of Japan's First Official Community 'Cloud Native Community Japan' to Promote Cloud Native Innovation" (December 1, 2023)https://www.hitachi.co.jp/New/cnews/month/2023/12/1201.html (Japanese only)Comment from Chris Aniszczyk, CTO of the CNCF"The Chop Wood Carry Water Award recognizes the essential, behind-the-scenes work that keeps our community strong," said Chris Aniszczyk, CTO, CNCF. "Yuichi Nakamura embodies that spirit by dedicating time and care to the often unseen but critical tasks, like improving documentation, and organizing meetups like the Cloud Native Community Japan (CNCJ). His steady commitment ensures that CNCF projects stay healthy, sustainable, and ready for the local community in Japan and also globally."Comment from Yuichi Nakamura, Head of Hitachi OSPO"I am deeply honored and grateful to receive this prestigious award from the CNCF. For over 20 years, I have dedicated myself to the development of the OSS community. As a Board Evangelist for The Linux Foundation (LF) and as the CNCF Governing Board*4, I serve as a bridge between Japan’s domestic OSS community and LF-related organizations, working to advance the OSS ecosystem within business contexts. Additionally, while fostering the growth and success of domestic engineers, I have contributed to enhancing the global value of Keycloak, an OSS project of the CNCF, as an authentication and authorization platform. More recently, I have actively shared insights on access control for AI agents*5 and advocated for establishing best practices. I will continue to contribute to solving global social issues within the OSS community."(*4) News Release "Head of Hitachi OSPO becomes a member of the Cloud Native Computing Foundation Governing Board" (February 28, 2025)https://www.hitachi.com/en/information/20250228/(*5) News Release "Launching HARC for AI to Maximize the Benefits of AI Agent Implementation" (October 7, 2025) https://www.hitachi.co.jp/New/cnews/month/2025/10/1007.html (Japanese only)BackgroundIn recent years, cloud native and AI technologies utilized in digital transformation have seen rapid expansion of their capabilities within the OSS community. Notably, the CNCF, with over 720 member organizations worldwide and engineers globally participating in development, contributes significantly to advancing cloud native technologies essential as the foundation for AI. However, as of 2023, Japan lacked a community bridging the CNCF with local companiesand organizations, and there were few cloud native technologies originating from Japan. Therefore, Nakamura spearheaded the establishment of CNCJ, an organization that connects the global CNCF development community with Japanese companies and existing organizations. He has dedicated himself to community management and outreach activities, such as encouraging participation from engineers at Japanese companies. Nakamura's BackgroundHead of OSPO, Ph.D. (Engineering) with Hitachi, Ltd.2001–present: Engaged in OSS security R&D, leading the promotion of SELinux*6 in Japan and contributing significant code to the community2015: Recognized for OSS development activities related to SELinux, received the "Kiyasu Memorial Achievement Award" from the Information Processing Society of Japan alongside OSS security community membersLaunched an API management solution utilizing OSS Keycloak and trained maintainers2022: Appointed as a board member of The Linux Foundation2023: Participated in establishing CNCJ, the Japan Chapter of the CNCF2024: Appointed as the inaugural Evangelist for LF Japan2024: Appointed as Head of Hitachi OSPO2025: Appointed as the CNCF Governing Board(*6) SELinux (Security-Enhanced Linux) is a built-in Linux kernel module that enables granular control over users who can access Linux systems.Hitachi Major OSS ActivitiesHitachi has contributed to the promotion and expansion of OSS in Japan since the founding of LF in 2000 as a sponsor. We have worked to enhance the reliability of the Linux kernel and to develop features in Keycloak that comply with European and South American standards for financial security through community activities. Our long-standing track record has been recognized, with Hitachi employees playing active roles in the global community as CNCF Ambassadors, Tech Lead of the TAG Security and Compliance group*7, and as maintainers*8*9 for Keycloak and Hyperledger Fabric. The Hitachi Group continues its global adoption efforts. In recent years, Hitachi has also provided cutting-edge insights and expertise in AI agent data access control through CNCF-related projects and domestic/international communities.(*7) Announcement: "Hitachi Employee Appointed as Initial Tech Lead of CNCF TAG Security and Compliance" (August7, 2025) https://www.hitachi.com/en/information/20250807/(*8) Announcement: "Hitachi Employee Appointed as Maintainer for OSS 'Keycloak' Development Project" (October 26, 2021) https://www.hitachi.co.jp/products/it/oss/news/20211026.html (Japanese only)(*9) Announcement: "Hitachi Employee Becomes Core Maintainer for Enterprise Blockchain OSS 'Hyperledger Fabric’ Development Project—First Japanese Company to Do So" (April 18, 2024)https://www.hitachi.co.jp/products/it/blockchain/topics/20240418.html (Japanese only)Related SitesHitachi OSS (Open Source Software) https://www.hitachi.co.jp/products/it/oss/index.html (Japanese only)TrademarksOther organization and product names are trademarks or registered trademarks of their respective organizations.About Hitachi, Ltd.Through its Social Innovation Business (SIB) that brings together IT, OT(Operational Technology) and products, Hitachi contributes to a harmonized society where the environment, wellbeing, and economic growth are in balance. Hitachi operates globally in four sectors - Digital Systems & Services, Energy, Mobility, and Connective Industries - and the Strategic SIB Business Unit for new growth businesses. With Lumada at its core, Hitachi generates value from integrating data, technology and domain knowledge to solve customer and social challenges. Revenues for FY2024(ended March 31, 2025) totaled 9,783.3 billion yen, with 618 consolidated subsidiaries and approximately 280,000 employees worldwide. Visit us at www.hitachi.com. Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
The University of Osaka D3 Center and NEC Demonstrate Wide-Area Distributed Campus AI Processing Platform JCN Newswire

The University of Osaka D3 Center and NEC Demonstrate Wide-Area Distributed Campus AI Processing Platform

TOKYO, Nov 13, 2025 - (JCN Newswire via SeaPRwire.com) - The University of Osaka D3 Center and NEC Corporation (NEC; TSE: 6701) have jointly commenced a demonstration aimed at the application of a wide-area distributed campus AI processing platform that enables on-demand use of GPU’s from compute servers. This demonstration will leverage NEC's "ExpEther," a technology that transmits signals from IT equipment with high reliability and low latency, to build a high-performance AI processing platform that can connect and disconnect compute servers and GPUs on-demand, even when they are in different buildings across campus.In recent years, the necessity and importance of AI analysis and utilization for vast amounts of sensitive data, such as genome data and clinical trial data, have rapidly increased. This data requires strict management, making it difficult to utilize computing infrastructure that is shared by an unspecified number of users. Therefore, there is a demand for technology that enables secure data management in a safe environment, along with on-demand access to a secure computing environment for AI analysis and utilization of the data.NEC's ExpEther transfers PCI Express communications, which are typically conducted inside computers, over Ethernet. This enables high-speed and seamless connection and disconnection of devices such as CPUs, GPUs, and storage located at distant locations, as if they were part of a single system. This demonstration will utilize ExpEther to build a wide-area distributed AI processing platform that can connect and disconnect GPUs located in a remote data center on-demand from a research lab's compute server, and will verify its effectiveness and usefulness. Furthermore, based on the results of this demonstration, the organizations aim to establish a wide-area distributed campus AI processing platform that can safely utilize sensitive data handled by research institutes, such as the Institute of Scientific and Industrial Research, and various departments.Outline of the DemonstrationIn this demonstration, a GPU (NVIDIA H100NVL) installed as a resource pool in the D3 Center IT Core Building on The University of Osaka's Suita Campus will be connected to a compute server (Express5800/R120j-2M) located in the main building. This connection will be established using ExpEther via a 100Gbps Ethernet optical fiber. In this environment, operational checks and performance verification will be conducted, focusing on AI applications that utilize GPUs.1. Application of a Wide-Area Distributed Computing Platform Enabling On-demand Configuration on a Campus ScaleGPUs consolidated and pooled as resources in D3 Center IT Core Building will be able to be connected and disconnected on-demand from compute servers located in remote research institutes and departments. By deploying this technology, the demonstration aims to build an AI processing platform that allows research lab compute servers to utilize remotely located GPUs on-demand.2. Efficiency Improvement through GPU Consolidation and SharingExpensive computing resources such as GPUs will be centrally managed as a common resource pool, aiming to optimize university-wide capital investment, reduce resource waste, and improve GPU utilization efficiency.Future VisionThe University of Osaka D3 Center and NEC aim to build a wide-area distributed campus AI processing platform that allows compute servers located in various buildings across the campus to connect and utilize pooled high-performance GPUs and SSDs on-demand. D3 Center also plans to offer dedicated storage services for the safe operation and management of sensitive data, such as clinical trial data and genomic information, handled by the Institute of Scientific and Industrial Research and other entities. This platform aims to achieve a secure AI processing platform that can safely utilize sensitive data by combining the strict operation of sensitive data with the dynamic system reconfigurability enabled by ExpEther. This will contribute to improving the productivity of research activities involving sensitive data. Going forward, the organizations will further deepen joint research and contribute to the creation of innovation in academic research.NEC will organize and resolve technical issues for the application of a remote shared GPU utilization platform based on the knowledge gained from this demonstration, aiming for commercialization of the solution in fiscal year 2026.NEC will exhibit ExpEther, utilized in this demonstration, at its booth during SC25: The International Conference for High Performance Computing, Networking, Storage, and Analysis, to be held from November 16 to 21, 2025, in St. Louis, USA."The wide-area distributed campus AI processing platform currently being built in this demonstration holds significant meaning for the realization of the bioinformatics platform concept promoted by The University of Osaka. Flexible utilization of high-performance computing resources is indispensable for multiple departments and graduate schools to collaborate and advance the analysis of vast amounts of data in the life sciences and medical fields. We expect that its practical application will significantly accelerate cross-departmental collaborative research and large-scale data analysis, as computing environments previously limited to individual laboratories or departments can now be safely and efficiently shared across the entire campus," said Professor Masateru Taniguchi, SANKEN (The Institute of Scientific and Industrial Research), The University of Osaka."This demonstration holds great significance as a potential solution to the challenge of balancing the expectations and interest in AI utilization in the life sciences and medical fields with confidential information management. By on-demand connection and disconnection of securely managed data resources and high-performance computing resources essential for future academic research, we can provide a dedicated secure AI processing platform for any research group. If the handling of sensitive data, which was previously difficult from a data security perspective, becomes possible, it will dramatically increase the productivity of academic research areas using sensitive data at The University of Osaka. This enables the promotion of new research formats for cross-disciplinary and inter-organizational collaboration, where even research using sensitive data can flexibly utilize cutting-edge AI platforms. To realize the bioinformatics platform concept, we will continue to stabilize and expand this platform, leading research innovation across the university," said Professor Susumu Date, D3 Center, The University of Osaka.About The University of OsakaThe University of Osaka was founded in 1931 as one of the seven imperial universities of Japan and is now one of Japan's leading comprehensive universities with a broad disciplinary spectrum. This strength is coupled with a singular drive for innovation that extends throughout the scientific process, from fundamental research to the creation of applied technology with positive economic impacts. Its commitment to innovation has been recognized in Japan and around the world. Now, The University of Osaka is leveraging its role as a Designated National University Corporation selected by the Ministry of Education, Culture, Sports, Science and Technology to contribute to innovation for human welfare, sustainable development of society, and social transformation. Website: https://resou.osaka-u.ac.jp/enAbout NEC CorporationNEC Corporation has established itself as a leader in the integration of IT and network technologies while promoting the brand statement of “Orchestrating a brighter world.” NEC enables businesses and communities to adapt to rapid changes taking place in both society and the market as it provides for the social values of safety, security, fairness and efficiency to promote a more sustainable world where everyone has the chance to reach their full potential. For more information, visit NEC at https://www.nec.com. Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
Toyota to Invest Up to $10 Billion Additional in Its U.S. Operations Over the Next Five Years JCN Newswire

Toyota to Invest Up to $10 Billion Additional in Its U.S. Operations Over the Next Five Years

Toyota City, Japan, Nov 13, 2025 - (JCN Newswire via SeaPRwire.com) - Toyota Motor Corporation (Toyota) announced an additional investment of up to 10 billion USD in the United States over the next five years. This will bring the company's total U.S. investment to nearly 60 billion USD since beginning operations in the U.S. nearly 70 years ago.In addition, Toyota held an opening ceremony for Toyota Battery Manufacturing, North Carolina (TBMNC). Now officially starting production, the facility was established in November 2021 as Toyota's first in-house battery manufacturing company outside Japan. TBMNC is Toyota's 11th manufacturing facility in the U.S., representing an investment of nearly 14 billion USD and the creation of up to 5,100 new jobs.The new battery plant is part of Toyota's "best-company-in-town" approach-investing and producing locally, contributing to the local community and offering diverse options tailored to local needs through a multi-pathway strategy. In the U.S., it employs approximately 50,000 people and has been involved in the development and manufacturing of over 35 million vehicles across 11 manufacturing plants.Tetsuo Ogawa, president and chief executive officer, Toyota Motor North America, said: "Today's launch of Toyota's first U.S. battery plant and additional U.S. investment up to $10 billion marks a pivotal moment in our company's history. Toyota is a pioneer in electrified vehicles, and the company's significant manufacturing investment in the U.S. and North Carolina further solidifies our commitment to team members, customers, dealers, communities, and suppliers."Toyota Motor Corporation works to develop and manufacture innovative, safe and high-quality products and services that create happiness by providing mobility for all. We believe that true achievement comes from supporting our customers, partners, employees, and the communities in which we operate. Since our founding over 80 years ago in 1937, we have applied our Guiding Principles in pursuit of a safer, greener and more inclusive society. Today, as we transform into a mobility company developing connected, automated, shared and electrified technologies, we also remain true to our Guiding Principles and many of the United Nations' Sustainable Development Goals to help realize an ever-better world, where everyone is free to move.SDGs Initiatives: https://global.toyota/en/sustainability/sdgs/ Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
MHI Thermal Systems Launches Magnetic Bearing Centrifugal Chiller “ETI-N” Series for Japanese Market JCN Newswire

MHI Thermal Systems Launches Magnetic Bearing Centrifugal Chiller “ETI-N” Series for Japanese Market

Magnetic Bearing Centrifugal Chiller "ETI-N" Series TOKYO, Nov 13, 2025 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Heavy Industries Thermal Systems, Ltd. (MHI Thermal Systems), a part of Mitsubishi Heavy Industries (MHI) Group, is pleased to announce the launch of its newly developed magnetic bearing centrifugal chiller, the "ETI-N" series, for the Japanese market.The magnetic bearing centrifugal chiller the "ETI-N" series features a magnetic bearing compressor that levitates and supports the rotating shaft inside the compressor using magnetic levitation forces. This oil-free design eliminates the lubrication oil system and prevents sliding parts from being worn, thereby removing the necessity for periodic oil replacement work. As a result, the series significantly reduces maintenance work.At the same time, the necessary procedures in conventional centrifugal chillers to start the oil pump and the time needed for the lubricating oil film to be formed have been eliminated. As a result, the ETI-N realizes the quick start, contributing to improved operational efficiency for our customers.The ETI-N series offers compact small to medium capacity models ranging from 150 to 700 refrigeration tons(*1). Equipped with a built-in inverter as standard on the chiller unit, the series reduces transportation and installation work. It delivers high efficiency with a rated COP(*2) of 6.4 and an IPLV(*3) of 9.1. The refrigerant, HFO-1233zd(E), a non-flammable, non-ozone-depleting refrigerant with a global warming potential (GWP)(*4) of 1 is used, underscoring the product's commitment to reducing environmental impact.MHI Thermal Systems has a proven track record of delivering products that combine greener environmental performance and higher equipment performance, including the ETI-Z series launched in 2015 using HFO-1233zd(E), the GART-ZE/ZEI series introduced in 2017 with HFO-1234ze(E), and the JHT-Y/YI series released in 2022 using HFO-1234yf. The addition of the magnetic bearing centrifugal chiller "ETI-N" series further enriches the product lineup, providing customers with a wider range of options tailored to their specific applications.As part of the Mitsubishi Heavy Industries Group, which has declared its goal of achieving carbon neutrality by 2040, MHI Thermal Systems is actively engaged in reducing CO2 emissions from its production facilities as well as from customer operations through its products. MHI Thermal Systems is leading domestic market share for centrifugal chillers used in general air conditioning, industrial air conditioning, factory processes, and district heating and cooling. Moving forward, MHI Thermal Systems will continue to meet customer needs while contributing to a carbon-neutral society by delivering environmentally friendly centrifugal chillers and thermal solution products.(*1) Refrigeration ton (RT) is a unit of cooling capacity, with 1 RT = approx. 3.516 kilowatts (kW).(*2) Coefficient of performance (COP) is a performance coefficient calculated based on Japanese Industrial Standards (JIS). Higher values indicate greater energy efficiency.(*3) Integrated part load value (IPLV) is the period coefficient of performance, calculated considering load fluctuations throughout the year, under load ratio and cooling water temperature conditions close to actual use.(*4) Global Warming Potential (GWP) is a coefficient expressing the greenhouse effect of a gas relative to carbon dioxide (CO2), which has a fixed GWP of 1.0. Smaller values indicate better environmental performance.About MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
MHI Completes Joint Demonstration with Kirin Group for Automation of Warehouse Operations, and Truck Loading and Unloading JCN Newswire

MHI Completes Joint Demonstration with Kirin Group for Automation of Warehouse Operations, and Truck Loading and Unloading

Demonstration testing at Kirin Group Logistics' Nishi-Nagoya facility TOKYO, Nov 13, 2025 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Heavy Industries, Ltd. (MHI) completed a joint demonstration with Kirin Beverage Co., Ltd. and Kirin Group Logistics Co., Ltd. to establish the elemental technologies for automation of inbound and outbound warehouse operations at beverage warehouses, and truck loading and unloading. Going forward, the companies will pursue further development and verification with the aim of practical application.The joint demonstration, begun in August 2024, was conducted at LogiQ X Lab, a demonstration facility located within Yokohama Hardtech Hub (YHH), MHI's co-creation space in Honmoku, Yokohama, and at Kirin Group Logistics' Nishi-Nagoya facility and other sites.(*1)For this joint demonstration, MHI utilized a new type of unmanned forklift that is currently under development equipped with ΣSynX (Sigma Syncs)(*2), part of the "Smart Connections" solutions incorporating ΣSynX technology. The demonstration tests aimed to establish elemental technologies to enable flexible autonomous operation and safe human-machine coordination, including appropriate load assortment in warehouse work, altering of operational routes in response to changes in placement locations and storage conditions, and highly efficient storage methods.Through this joint demonstration, MHI has established the processes for future automation of the entire cargo handling process, including unloading of trucks, warehouse handling, and loading onto trucks, and was able to verify the effectiveness of these processes at actual logistics facilities.MHI categorized routine logistics warehouse work, which up to now has been conducted safely and efficiently through the expertise, experience and skill of operators, into the three areas of picking, inbound and outbound processes, and the loading and unloading of trucks, and progressively implemented measures incorporating ΣSynX for automation and intelligence. An automated picking solution for cargo handling inside the warehouse was put into operation in December 2024 at Kirin Group's Ebina Logistics Center in Kanagawa Prefecture.(*3) Based on the results of this joint demonstration, MHI will continue to work to enhance the scalability of its "Smart Connections" solutions in all areas of logistics and warehouse operations.Going forward, MHI will continue to contribute to society by more deeply developing "Smart Connections" solutions incorporating ΣSynX to address the various issues facing the logistics industry, including the shortage of logistics operators, improvement in working conditions, and the challenges posed by regulatory changes implemented in 2024 aimed at reducing working hours and waiting times for truck drivers.(*1) For more information on "MHI begins joint demonstration with the Kirin Group for automation of inbound and outbound warehouse processes, and loading and unloading of trucks", see the following press release.https://www.mhi.com/news/24082201.html(*2) ΣSynX is MHI's standard platform for synchronizing and coordinating various types of machinery systems. It brings together a range of digital technologies to make machinery systems intelligent and allow for optimized operation. For more information, see the following press release.https://www.mhi.com/news/23100501.html(*3) For more information on the joint demonstration with the Kirin Group for an automated picking solution, see the following press release.https://www.mhi.com/news/22112101.htmlOverview of the Joint Demonstration- PeriodAugust 1, 2024, to September 30, 2025- Demonstration sites(MHI)LogiQ X Lab demonstration facility at Yokohama Hardtech Hub (YHH)Demonstration facility at Kobe Shipyard(Kirin Group Logistics)Nishi-Nagoya facility- Demonstration content* Determination of operational processes, including manned work, assuming the introduction of warehouse inbound and outbound process solutions* Determination of operational processes, including manned work, assuming the introduction of unmanned forklifts for loading and unloading trucks* Determination of safety concepts, rules, operating conditions, and other standards for collaborative work with manned and unmanned forklifts "Smart Connections" solutions incorporating ΣSynX About MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
JCB launches second round of Shopping Mall Shuttle Free Ride Campaign in Guam JCN Newswire

JCB launches second round of Shopping Mall Shuttle Free Ride Campaign in Guam

TOKYO & GUAM, Nov 13, 2025 - (JCN Newswire via SeaPRwire.com) - JCB International Co., Ltd., the international operations subsidiary of JCB Co., Ltd., Japan’s only international payment brand, and T.P. Micronesia, Inc. (Lam Lam Tours and Transportation), a group company of JTB Corp., are launching the second round of the Shopping Mall Shuttle Free Ride Campaign in Guam. The campaign will run from November 1, 2025 to March 31, 2026, continuing the successful shuttle bus initiative now in its fourth year.JCB offers a complimentary rides on the Shopping Mall Shuttle route of the Red Guahan Shuttle, which connects Guam's major shopping centers—Micronesia Mall, Dusit Place, K Mart, Guam Premier Outlets, and Village of Donki—via the hotel district.To enjoy the free ride, JCB cardmembers simply present JCB Cards[1] to the driver when boarding. Each cardmember is eligible for free transportation for themselves and up to two accompanying children[2].Following the strong positive response from visitors during the first campaign held in early 2025, JCB has decided to launch this second round using the same popular route.For more information, please visit here.To explore other exclusive offers and services for JCB cardmembers worldwide, visit here.[1] Prepaid and virtual cards are not eligible.[2] Non-eligible passengers must purchase a ticket. Children aged 5 and under travel free of charge.About Shopping Mall ShuttleThe Shopping Mall Shuttle is a fixed route bus service that provides transportation in Guam, connecting Guam's hotel districts to places such as major shopping centers.About Lam Lam Tours and TransportationT.P. Micronesia, Inc. dba Lam Lam Tours & Transportation owns a fleet of large buses, limousines, trolleys, and other vehicles and provides a variety of transportation services in Guam, including the Red Guahan Shuttle, shuttles between the airport and hotels, and chartered buses.About JCBJCB is a major global payment brand and a leading credit card issuer and acquirer in Japan. JCB launched its card business in Japan in 1961 and began expanding worldwide in 1981. Its acceptance network includes about 56 million merchants around the world. JCB Cards are now issued mainly in Asian countries and territories, with more than 169 million cardmembers. As part of its international growth strategy, JCB has formed alliances with hundreds of leading banks and financial institutions globally to increase its merchant coverage and cardmember base. As a comprehensive payment solution provider, JCB commits to providing responsive and high-quality service and products to all customers worldwide. For more information, please visit: www.global.jcb/en/ContactAnna TakedaCorporate CommunicationsTel: +81-3-5778-8353Email: jcb-pr@info.jcb.co.jp Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
Establishment of the AI Technology “Large Action Model (LAM)” to Accelerate 1-to-1 Marketing JCN Newswire

Establishment of the AI Technology “Large Action Model (LAM)” to Accelerate 1-to-1 Marketing

Using Large Action Model (LAM) trained on time-series data obtained from various customer touchpoints, such as online and in-store interactions, NTT and DOCOMO have achieved personalized 1-to-1 marketing tailored to each customer’s individual needs.The research and development of LAM was led by NTT. By pre-learning patterns in behavioral sequences from customer time-series data to predict customers’ intent, and then further learning the content, method, timing, and effectiveness of promotional measures to personalize them, the model was designed to flexibly accommodate diverse promotional strategies.DOCOMO was responsible for integrating customer data into the “4W1H” format (Who, When, Where, What, and How), constructing the LAM, and verifying the effectiveness of promotional measures. As a result, telemarketing orders for mobile and smart life-related services increased by up to 2 times compared to conventional methods.TOKYO, Nov 12, 2025 - (JCN Newswire via SeaPRwire.com) - NTT, Inc. (Headquarters: Chiyoda-ku, Tokyo; President and CEO: Akira Shimada; hereinafter "NTT") and NTT DOCOMO, INC. (Headquarters: Chiyoda-ku, Tokyo; President and CEO: Yoshiaki Maeda; hereinafter "DOCOMO") have established a new AI technology called the Large Action Model (LAM) which predicts customers’ intent based on time-series data organized in the “4W1H” format (Who, When, Where, What, and How) collected from various customer touchpoints, including online channels and physical stores. This technology enables highly personalized 1-to-1 marketing tailored to each customer’s needs. LAM is a generative AI technology specialized for time-series data that includes both numerical and categorical data, possessing a structure similar to large language models (LLMs).NTT was responsible for the research, development, and tuning of the model, while DOCOMO handled the integration of customer data, the construction of the LAM, and the verification of the promotional effectiveness.*1 As a result, the order rate for mobile and smart life-related services through telemarketing improved by up to 2 times compared with conventional methods.Furthermore, through innovations in design and parameter optimization, DOCOMO’s proprietary LAM was successfully built using less than one day of computation, equivalent to approximately 145 GPU hours, on a GPU server equipped with eight NVIDIA A100 (40GB) units.The research results will be exhibited at NTT R&D FORUM 2025 IOWN ∴Quantum Leap*2, to be held from November 19 to 26, 2025.Figure 1 Overview of the initiativeBackground and Challenges in Advancing MarketingAs companies aim to enhance customer satisfaction and create new revenue opportunities, advancing marketing strategies has become a key challenge. Until recently, most companies relied on “segment marketing,” which groups customers based on attributes such as age or gender and provides tailored proposals to each group. In recent years, however, “1-to-1 marketing,” which offers personalized proposals for each individual customer, has been gaining attention, creating a need for more precise customer understanding.To effectively implement 1-to-1 marketing, it is essential to utilize sequential behavioral data obtained from various daily customer touchpoints and to understand customer needs based on the entire process leading up to product purchases or service subscriptions, known as the customer journey. However, because the frequency and format of data differ across touchpoints, integrating and analyzing time-series data has been technically challenging. For example, app usage generates high-frequency operational logs, while in-store data mainly consist of lower-frequency data such as purchased items and payment methods. Integrating these diverse datasets in a unified manner is difficult, and when trying to further account for combinations and sequences of customer interactions, the complexity and computational cost of analysis increase significantly.To address these challenges, NTT and DOCOMO jointly focused on solving them by selecting DOCOMO’s telemarketing operations as a use case for 1-to-1 marketing.Development Background and CollaborationDOCOMO has developed the “CX Analytics Platform,” which converts diverse customer touchpoint data into unified time-series data formatted according to the 4W1H format (Who, When, Where, What, and How). This platform has helped improve the efficiency of data utilization across marketing initiatives.Meanwhile, NTT has been conducting research and development on an AI technology called LAM, which learns and predicts patterns of behavioral sequences in time-series data that includes both numerical and categorical data (Figure 2). This technology has an architecture similar to large language models (LLMs) and enables future behavior prediction with a Transformer*3-based model.In this collaboration, the two companies integrated their respective technologies. By leveraging DOCOMO’s CX Analytics Platform to consolidate customer data into time-series form and applying NTT’s LAM with an optimized tuning method, they built DOCOMO’s proprietary LAM, achieving significant reductions in computational cost.Figure 2 LAMSummary of Results- Establishment and Optimization of the LAM TechnologyWhen dealing with large-scale models and data, improving prediction performance often comes at the cost of increased computational load. In this project, through careful design and parameter optimization, DOCOMO successfully built its proprietary LAM with a total computation cost of 145 GPU hours (132 GPU hours for pre-training and 13 GPU hours for additional training).During pre-training, parameters necessary for predicting customers’ intended actions were optimized. During additional training, parameters required for personalizing promotional activities were fine-tuned. The total computation time corresponds to less than one day on eight NVIDIA A100 (40GB) GPUs.For reference, this efficiency is approximately 1/568 of training Llama-1 7B, an open-source large language model that requires 82,432 GPU hours (see Figure 3). As a result, DOCOMO has accumulated expertise in building cost-effective LAM models and successfully applied this know-how to real-world marketing use cases.Figure 3 Comparison of construction costs between LAM and in-market LLM- Operational Improvements through 1-to-1 MarketingUsing DOCOMO’s proprietary LAM, customer needs and the necessity of telemarketing were quantified as scores. By prioritizing customers with higher necessity scores, the order rate for mobile and smart life-related services improved by up to 2 times compared to conventional methods (Figure 4).Interviews with several customers who received proposals revealed that the system enabled outreach at appropriate timings, such as to those who wished to complete procedures in-store but found it difficult to visit due to childcare, or to those who were undecided about changing their rate plans.Figure 4 Example application in the marketing sectorRoles of Each CompanyNTTResponsible for the research and development of LAM and the provision of tuning methods.DOCOMOResponsible for the research and development of the CX analytics platform, the training and inference of LAM using authorized personal information, and the provision of telemarketing services.Key Technical Features- CX Analytics PlatformAn analytics platform that supports service improvement by integrating a wide range of online and offline services and deepening customer understanding provided by DOCOMO. By organizing data in the 4W1H format (Who, When, Where, What, and How), it enables unified handling of data collected from diverse customer touchpoints.- LAMA Transformer-based time series prediction AI developed by NTT (Figure 2). It can handle mixed numerical and categorical data, including those with missing or biased values.The model captures differences in meaning based on the order of customer actions. For example, consider three actions: telemarketing, product page browsing, and purchase (Figure 5).If a customer receives a telemarketing call, then views a product page, and finally makes a purchase, telemarketing can be interpreted as promoting product awareness.If the sequence is browsing followed by telemarketing and then purchase, telemarketing is likely to have deepened the customer’s interest in the product.In contrast, if telemarketing occurs after purchase, it may indicate after-sales support for a potential issue.By distinguishing these contextual differences, the model enhances customer understanding and accurately predicts each customer’s intent.Furthermore, the model improves learning efficiency through innovations such as a hierarchical Transformer structure that progressively aggregates data with different frequencies and formats.Figure 5 Examples showing how the meaning of actions differs depending on their orderApplications of the LAM TechnologyNTT is exploring the potential applications of LAM technology across a wide range of fields. The know-how gained in building cost-effective LAM models is expected to be leveraged in other domains as well.* HealthcareIn the medical field, patients’ treatment histories are recorded as time-series data in electronic medical records. The order of disease progression and medication prescriptions carries important clinical meaning, and analyzing these patterns can provide valuable insights for treatment support. To this end, NTT is applying LAM technology to support diabetes treatment (Figure 6) *4.Figure 6 Example application in the health sector* Energy SectorSatellite and ground-based observations of meteorological phenomena are also recorded as time-series data. Solar power operators use these time-series data to forecast future solar radiation, develop generation plans, and conduct electricity trading with retail power suppliers. Fluctuations in the power output of geographically adjacent solar power facilities reflect the effects of cloud movement and position on solar radiation. Analyzing these patterns is useful for improving the accuracy of solar radiation forecasts. Therefore, NTT is also working on applying LAM to solar radiation forecasting (Figure 7).Figure 7 Example application in the energy sectorFuture DevelopmentsTo address real-world challenges through data-driven approaches, NTT will continue to enhance LAM technology. By 2028, we aim to improve the flexibility of data input and output for LAM, enabling it to handle most types of nonverbal data used in our business operations.DOCOMO will continue striving to offer personalized proposals for each individual customer.Related InformationIntroduction video of LAM: https://youtu.be/71nAVN0pvPg(*1) Personal data are handled appropriately in accordance with our privacy policy.(*2) NTT R&D FORUM 2025 IOWN ∴Quantum Leap official website:https://www.rd.ntt/e/forum/2025/(*3) A Transformer is a type of neural network architecture that converts an input sequence into an output sequence.(*4) Kurasawa H, et al. Enhancing Antidiabetic Drug Selection Using Transformers: Machine-Learning Model Development. JMIR Med Inform. 2025 Jun 2;13:e67748. doi: 10.2196/67748. PMID: 40456113; PMCID: PMC12148250.About NTTNTT contributes to a sustainable society through the power of innovation. We are a leading global technology company providing services to consumers and businesses as a mobile operator, infrastructure, networks, applications, and consulting provider. Our offerings include digital business consulting, managed application services, workplace and cloud solutions, data center and edge computing, all supported by our deep global industry expertise. We are over $90B in revenue and 340,000 employees, with $3B in annual R&D investments. Our operations span across 80+ countries and regions, allowing us to serve clients in over 190 of them. We serve over 75% of Fortune Global 100 companies, thousands of other enterprise and government clients and millions of consumers.About NTT DOCOMONTT DOCOMO, Japan's leading mobile operator with over 91 million subscribers, is one of the global leaders in 3G, 4G and 5G mobile network technologies. Under the slogan “Bridging Worlds for Wonder & Happiness,” DOCOMO is actively collaborating with global partners to expand its business scope from mobile services to comprehensive solutions, aiming to deliver unsurpassed value and drive innovation in technology and communications, ultimately to support positive change and advancement in global society. https://www.docomo.ne.jp/english/ Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
Mitsubishi Power Receives Second H-25 Gas Turbine Order for Chang Chun Petrochemical’s Miaoli Factory in Taiwan JCN Newswire

Mitsubishi Power Receives Second H-25 Gas Turbine Order for Chang Chun Petrochemical’s Miaoli Factory in Taiwan

Cogeneration Facility at Miaoli Factory (Photo: Chang Chun Petrochemical) TOKYO, Nov 12, 2025 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Power, a power solutions brand of Mitsubishi Heavy Industries, Ltd. (MHI), has received an order for an H-25 gas turbine for Chang Chun Petrochemical Co., Ltd. through Mitsubishi Corporation Machinery, Inc.Chang Chun Petrochemical is advancing plans to convert the cogeneration facility at its Miaoli Factory, located in Miaoli City in north-central Taiwan, from existing heavy oil and coal-fired boilers to a high-efficiency natural gas-fired system. The H-25 gas turbine will serve as the core of the new gas-fired cogeneration facility, with an output of approximately 30 MW. Operation is scheduled to begin around the end of 2028, supplying electric power and steam for manufacturing processes at the factory. Mitsubishi Power will deliver the main gas turbine and auxiliary equipment, as well as dispatch engineers to support equipment installation and commissioning.Mitsubishi Power previously received an order for an H-25 gas turbine for the Miaoli Factory in 2023, with operation planned to start around summer 2026. This order marks the second H-25 gas turbine to be installed at the same factory. Through improved plant efficiency and reduced CO2 emissions, this project will contribute to the realization of Taiwan's energy policy objectives.Chang Chun Petrochemical is a core company of Chang Chun Group, a major petrochemical conglomerate in Taiwan. Headquartered in Taipei, Chang Chun Group comprises numerous group companies and factories in Taiwan and around the world.Since 1984, Mitsubishi Power has supplied major equipment to power generation and cogeneration facilities at Chang Chun Group factories, including nine steam turbines and five boilers. Mitsubishi Power continues to provide after-sales services and various solution offerings. This latest order reflects the strong trust earned through this track record and the long-standing positive relationship between the two companies.The H-25 gas turbine has demonstrated high reliability supported by extensive long-term operational experience. Since receiving the initial order for the H-25 in 1987, Mitsubishi Power has delivered and operated more than 200 units worldwide. Utilizing the H-25 in cogeneration facilities enables improved plant efficiency and reduced CO2 emissions compared to conventional boiler-based systems that burn fuel directly.Mitsubishi Power will continue to actively expand its business in the distributed power generation market, including industrial private power generation and cogeneration systems worldwide, contributing to the strengthening of industrial infrastructure and the reduction of energy-related environmental impacts globally.About MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
All-New Delica Mini and eK Space Win RJC Car of the Year Award for 2026 JCN Newswire

All-New Delica Mini and eK Space Win RJC Car of the Year Award for 2026

TOKYO, Nov 11, 2025 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Motors Corporation (hereafter, Mitsubishi Motors) announced that its all-new kei-cars1, the Delica Mini and eK Space, have been jointly awarded the RJC Car of the Year award for 2026, run by the Automotive Researchers’ and Journalists’ Conference of Japan (RJC), alongside the Nissan Roox.Additionally, Mitsubishi Motors rally driver Hiroshi Masuoka has been honored with the RJC Person of the Year award for 2026. This prestigious accolade recognizes outstanding individuals in the automotive industry. All-New eK Space and Delica Mini Hiroshi MasuokaVice President, Mitsubishi Motors RJC Car of the Year AwardThis marks Mitsubishi Motors’ fifth win of the RJC Car of the Year award and the first in three years since the eK X EV (pronounced "eK 'cross' EV"), an all-electric kei-car, won the award2 for 2023.The Delica Mini is a super height-wagon kei-car that bears the name of the Delica minivan, which combines a spacious interior with powerful driving performance. The all-new model builds on the concept of its predecessor while making bold advancements in exterior and interior design, driving performance, safety features, ease of handling, and user-friendliness, making it ideal for both everyday driving and outdoor adventures.The all-new eK Space combines excellent maneuverability for city driving with a modern design that appeals to all generations, along with a spacious interior.* Comments from the Jury:While further enhancing the visibility and convenience expected of super height-wagon kei-cars, the models achieve both excellent fuel efficiency and refined driving performance. By incorporating unique elements into the interior and exterior designs to create three distinctive models – each built on a single platform developed by NMKV Co., Ltd., a joint venture between Nissan Motor Co., Ltd. and Mitsubishi Motors – the achievement demonstrates exceptional ingenuity and deserves significant praise.RJC Person of the Year AwardHiroshi Masuoka has competed in the Dakar Rally 21 times with Mitsubishi vehicles including the Pajero, achieving consecutive victories in 2002 and 2003, the first ever by a Japanese driver. From 2012 to 2014, he participated in the Pikes Peak International Hill Climb, and in 2015 in the Baja Portalegre, driving electrified vehicles as both a driver and team director.By participating in motorsports with competition vehicles based on mass-production models, as well as those incorporating both production components and advanced technologies, he has leveraged the expertise gained to enhance commercial vehicles, contributing to the advancement of high-performance electrified vehicles that support carbon neutrality. Additionally, his proactive involvement in social contribution activities to promote safe driving, including participation in Mitsubishi Motors’ SUV 4WD test drive events, was highly praised, leading to his recognition with the award.Currently, Masuoka serves as team director of Team Mitsubishi Ralliart, leading the team to overall victories in the Asia Cross Country Rally in 2022 and 2025.* Comments from the Jury:Masuoka achieved the first-ever consecutive wins by a Japanese driver in the Dakar Rally, and as a team director, led his team to two victories in the Asia Cross Country Rally. By competing with electrified vehicles, he has contributed to the development of electrification technologies that promote environmental sustainability. His role as a demonstration driver in the 4WD hill climb kit experience event, along with his active efforts to promote safe driving, was also highly commended.* Comment from Hiroshi Masuoka:“From a young age, I was fascinated by cars and spent countless hours honing my skills. I debuted in off-road racing at 18 and joined Ralliart at 22. Over the years, I have had the honor of competing in the Dakar Rally – the world’s most grueling rally – 21 times with Mitsubishi Motors, achieving long-awaited overall victories in both 2002 and 2003. I am deeply grateful to Mitsubishi Motors customers, Team Mitsubishi Ralliart fans, all those involved, and my family, who has supported me throughout my journey of over 40 years as a driver and team director. I will continue to contribute to the development of safe, reassuring, and comfortable vehicles by applying the experience gained through motorsports.”About the RJC Car of the Year for 2026Now in its 35th year, the RJC Car of the Year award is determined by votes from RJC’s selection committee. Eligible vehicles are domestic models premiered in the Japanese market between November 1, 2024, and October 31, 2025. The top six models were selected on October 31, with final voting held on November 11.Mitsubishi Motors has previously won the RJC Car of the Year award four times3, the RJC Technology of the Year award six times4, and the Special Award twice5.1. Kei-car is a vehicle category in Japan for microcars.2. Joint award with the Nissan Sakura3. Previous winners include the "i" kei-car (award for 2007); the Eclipse Cross, a crossover SUV (award for 2019); the eK Wagon and eK X, height wagon kei-cars (award for 2020) and the eK X EV, an all-electric kei-car (award for 2023).4. Previously recognized technologies include the INVECS (Intelligent & Innovative Vehicle Electronic Control System) automatic transmission technology used in the Galant and Eterna (award for 1993); the INVECS-II Sport Mode automatic transmission of the FTO (award for 1995); the GDI (Gasoline Direct Injection) engine of the Galant and Legnum (award for 1997); the PHEV system of the Outlander PHEV (award for 2014); the evolved PHEV and S-AWC systems of the Eclipse Cross (award for 2022); and the electrification technology of the all-electric kei-car used in the eK X EV (award for 2023).5. Previous winners include the Lancer Evolution X (award for 2009) and the Triton (award for 2025).About Mitsubishi MotorsMitsubishi Motors Corporation (TSE:7211) — a member of the Alliance with Renault and Nissan — is a global automobile company based in Tokyo, Japan, which has about 28,000 employees and a global footprint with production facilities in Japan and the ASEAN region. Mitsubishi Motors has a competitive edge in SUVs, pickup trucks and plug-in hybrid electric vehicles, and appeals to ambitious drivers willing to challenge convention and embrace innovation. Since the production of our first vehicle more than a century ago, Mitsubishi Motors has been a leader in electrification — launched the i-MiEV, the world’s first mass-produced electric vehicle in 2009, followed by the Outlander PHEV, the world’s first plug-in hybrid electric SUV in 2013. With a target of increasing the sales ratio of electrified vehicles to 100% by 2035, Mitsubishi Motors will deliver models that embody Mitsubishi Motors-ness and contribute to the realization of a carbon-neutral society. For more information on Mitsubishi Motors, please visit the company's website at https://www.mitsubishi-motors.com/en/ Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
TANAKA PRECIOUS METAL TECHNOLOGIES Announces TK-SR Rhodium Material for Use in Probe Pins JCN Newswire

TANAKA PRECIOUS METAL TECHNOLOGIES Announces TK-SR Rhodium Material for Use in Probe Pins

TOKYO, Nov 12, 2025 - (JCN Newswire via SeaPRwire.com) - TANAKA PRECIOUS METAL TECHNOLOGIES Co., Ltd., an industrial precious metals organization, has announced the development of TK-SR, a rhodium (Rh) material for probe pins used in probe cards during the front-end processes of semiconductor package manufacturing. This first of its kind product will be exhibited on display at Booth 506 and panel displays at SWTest Asia 2025 from November 20 to November 21 in Fukuoka, Japan. "TK-SR" product image Comparison of stress-strain curve for probe Rh and conventional TANAKA RhTANAKA manufactures and supplies various precious metal probe pin materials for the inspection equipment used in the front- and back-end processes of semiconductor manufacturing. Using its proprietary processing technologies, TANAKA is the first company in the world to successfully develop a rhodium probe pin material that simultaneously offers high strength, elasticity, hardness, and electrical conductivity that will extend the lifespans of probe cards and lower their costs.TK-SR is available in widths as narrow as 18μm, enabling precision inspection for today’s increasingly compact narrow-pitch semiconductor packages. TANAKA plans to ship twice as many of these products as conventional products by 2030.Probe cards play a critical role in current-carrying tests on silicon wafers during front-end semiconductor processes, using thousands or sometimes tens of thousands of precision probe pins. These pins endure extremely light loads applied hundreds of thousands, or even millions, of times. If a single probe pin bends or breaks, it must be replaced, and in some cases, the entire probe card. That’s why durability is essential. TANAKA’s high-strength, high-elastic limit TK-SR significantly reduces the risk of deformation and breakage, minimizing replacement frequency and improving overall reliability.TK-SR Product Performance (reference values)Comparison of TK-SR and Convention Rh Wire PropertiesExhibition Details- Exhibition Name: SWTest Asia 2025- Dates and Times: November 20 to November 21, 2025, 8:00 a.m. to 5:00 p.m.- Location: Hilton Fukuoka Sea Hawk (Fukuoka, Japan)- Website: https://www.swtestasia.org/- Exhibitor: TANAKA PRECIOUS METAL TECHNOLOGIES Co., Ltd.- Booth No.: 506- Panel Contents: TK-SR (wire) rhodium material for probe pins, TK-FS (wire, plate), TK-SK (wire), palladium alloy material for probe pins, TK-101 (plate) copper and silver alloy material for probe pins, and plating solution for probe pins (various types)To learn more about TANAKA’s probe pin offerings and contributions to the semiconductor market, visit: https://tanaka-preciousmetals.com/en/products/detail/probe-pins/ About TANAKASince its foundation in 1885, TANAKA has built a portfolio of products to support a diversified range of business uses focused on precious metals. TANAKA is a leader in Japan regarding the volume of precious metals it handles. Over many years, TANAKA has manufactured and sold precious metal products for industry and provided precious metals in such forms as jewelry and assets. As precious metals specialists, all Group companies in Japan and worldwide collaborate on manufacturing, sales, and technology development to offer a full range of products and services. With 5,591 employees, the group’s consolidated net sales for the fiscal year ended December 2024 were 846.9 billion yen.TANAKA Industrial Precious Metal Materials Portalhttps://tanaka-preciousmetals.comProduct inquiriesTANAKA PRECIOUS METAL TECHNOLOGIES Co., Ltd.https://tanaka-preciousmetals.com/en/inquiries-on-industrial-products/Press inquiriesTANAKA PRECIOUS METAL GROUP Co., Ltd.https://tanaka-preciousmetals.com/en/inquiries-for-media/Press Release: https://www.acnnewswire.com/docs/files/20251112_EN.pdf Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
Hitachi and Tobu Railway launched a co-creation initiative to deliver HMAX on Japanese railways JCN Newswire

Hitachi and Tobu Railway launched a co-creation initiative to deliver HMAX on Japanese railways

TOKYO, Nov 11, 2025 - (JCN Newswire via SeaPRwire.com) - Hitachi and Tobu Railway Co., Ltd. ("Tobu Railway") have entered into a strategic partnership to Hitachi’s HMAX, a next-generation digital asset management platform on Tobu Railway’s train.The co-creation will focus on advancing the digital transformation of rolling stock maintenance, with key priorities including:- Automation of vehicle inspections- Optimization of manual operations- Strengthening on-site maintenance capabilities through digital toolsThrough its co-creation, Hitachi and Tobu Railway are committed to delivering the social innovations required for the sustainable railways of the future.Giuseppe Marino, Group CEO, Hitachi Rail, said: “Our HMAX technology is harnessing AI and data to power the digital transformation of rail, achieving greater reliability and efficiency across systems. Through partnerships, such as the co-creation announced today with Tobu Railway, we are leveraging our digital expertise to contribute to enhance performance, sustainability and passenger experience.”Mitsuo Iwasaki, Head of Japan Business, Hitachi Rail, said: “This co-creation marks a key milestone in transforming railway maintenance in Japan. We’re honored to begin co-creation with Tobu Railway and feel a strong sense of responsibility as we advance digitalization in this field. Hitachi will continue driving innovation to be an essential partner for Japan’s railway operators.”Takao Suzuki, Director, Managing Executive Officer, Head of Railway Business Division, Tobu Railway, said: “Hitachi has been responsible for the design and manufacturing of our rolling stock and onboard electronic equipment. With their extensive expertise in rolling stock maintenance, we believe that by implementing DX aligned with our maintenance methods, we can address challenges such as the labor shortage we will face in the future. The HMAX solution not only improves efficiency but also contributes to enhancing employee skills and engagement. By promoting co-creation with Hitachi, we aim to establish a sustainable railway business.”Drawing on the powerful digital expertise of the Hitachi Group, Hitachi Rail is applying AI technologies to transform mobility. In 2024, the company launched HMAX, its digital asset management platform, which harnesses NVIDIA’s AI and machine learning capabilities to optimize railway systems and infrastructure. Last month, Hitachi Rail was announced as the first transport company globally to adopt NVIDIA’s latest technology, its IGX Thor platform, to provide real-time processing at the edge. About Hitachi, Ltd.Through its Social Innovation Business (SIB) that brings together IT, OT(Operational Technology) and products, Hitachi contributes to a harmonized society where the environment, wellbeing, and economic growth are in balance. Hitachi operates globally in four sectors – Digital Systems & Services, Energy, Mobility, and Connective Industries –and the Strategic SIB Business Unit for new growth businesses. With Lumada at its core, Hitachi generates value from integrating data, technology and domain knowledge to solve customer and social challenges. Revenues for FY2024(ended March 31, 2025) totaled 9,783.3 billion yen, with 618 consolidated subsidiaries and approximately 280,000 employees worldwide. Visit us at www.hitachi.com.About Hitachi Rail:Hitachi Rail is committed to driving the sustainable mobility transition and has a clear focus on partnering with customers to rethink mobility. Its mission is to help every passenger, customer and community enjoy the benefits of more connected, seamless and sustainable transport.With revenues of over €7bn and 24,000 employees across more than 50 countries, Hitachi Rail is a trusted partner to the world’s best transport organisations. The company's reach is global, but the business is local - with success built on developing local talent and investing in people and communities.Its international capabilities and expertise span every part of the urban, mainline and freight rail ecosystems – from high quality manufacturing and maintenance of rolling stock to secure digital signalling, smart operations and payment systems. Hitachi Rail, famous for Japan's iconic high speed bullet train, draws on the digital and AI expertise of Hitachi Group companies to accelerate innovation and develop new technologies.Find out more by visiting hitachirail.com or our press site here. Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
uSMART Surpasses 1 Million Users, Expands to 10 Physical Service Centres across Hong Kong JCN Newswire

uSMART Surpasses 1 Million Users, Expands to 10 Physical Service Centres across Hong Kong

HONG KONG, Nov 10, 2025 - (ACN Newswire via SeaPRwire.com) – uSMART Securities Limited (“uSMART Securities/ the Company”), a strategic investment of Chow Tai Fook (Holding) Limited, is thrilled to announce the opening of its seventh physical service centre, the Causeway Bay branch. This expansion marks the Company's strategic entry into one of Hong Kong's most vibrant business and tourist districts. Conveniently located on Matheson Street near Times Square, the new branch represents uSMART Securities’ first on-floor presence on Hong Kong Island. It will further extending the customer reach and providing local investors with a welcoming space to learn and experience smart investing.Riding on the momentum of active stock market trading and a robust IPO cycle, Mr. Neo Lee, Executive Director of uSMART Securities, stated: “The Group’s user base has surpassed 1 million. As No.1 Hong Kong Funded Fintech Brokerage^, our market penetration continues to grow significantly. Building on this success, we plan to take another leap forward by opening 2 new branches in Tuen Mun and Tai Wai. All branches will create interactive, educational environments offering one-on-one consultation services and promoting inclusive finance for local investors.”Following the successful launch of its Lok Ma Chau and West Kowloon branches, uSMART Securities has accelerated its expansion with new openings in Tsuen Wan, Tsim Sha Tsui and Causeway Bay during the second half of this year. Together with its headquarters in Sheung Wan and Sheung Shui, the Company now operates 7 physical service centres across Hong Kong. The expansion continues with uSMART Securities' first Wealth Centre scheduled to open in January 2026, alongside with upcoming branches in Tuen Mun and Tai Wai, and 4 Group’s overseas service centres in Singapore and New York, bringing the Group’s total network to 14 service centres by the first quarter of 2026. This expansion demonstrates the company strength as the No.1 Hong Kong Funded Fintech Brokerage^ and its long-term commitment to serving local investors.“Concurrently, we are delighted to welcome renowned investment strategist Mr Dickie Wong, to join the company as Executive Director of Research. His leadership and expertise will strengthen our research capabilities, creating a powerful “1+1>2” synergy that deliver sharper, forward-looking analysis and generate greater value for our clients,” Neo continued.Furthermore, uSMART Securities made its debut at the “Hong Kong FinTech Week 2025”, one of the city’s premier financial events held last week. During the event, the Company showcased its strengths in fintech innovation and diverse investment products. Through in-depth exchanges with numerous industry leaders, uSMART Securities explored cutting-edge technology trends and successfully unlocked multiple opportunities for collaborative innovation and business development. Looking ahead, uSMART Group will remain committed to advancing financial technology innovation through a product-driven approach. By proactively responding to evolving client needs, the Company aims to strengthen its leadership position in the global fintech broker sector while fostering mutual growth with investors.Guided by its "client-first" philosophy, uSMART Securities will continue expanding its physical service network, integrating online platforms and offline experiences to deliver a seamless, next-generation investment journey that creates greater value for customers worldwide. “No.1 Hong Kong Funded Fintech Brokerage" is based on TradeGo Cloud data, with uSMART Securities ranking first in monthly transaction volume among local Hong Kong-funded internet brokers for over a year as of October 2025.About uSMART Securities:Strategic investments from Chow Tai Fook (Holding) Limited, uSMART Securities is a leading Hong Kong Funded Fintech Brokerage founded in 2018. Over the past seven years, it has pioneered the fusion of technology and finance, offering stocks trading, asset management, and wealth management solutions. Its proprietary platforms, uSMART HK APP and uSMART SG APP, operated by uSMART Securities (Hong Kong) and uSMART Securities (Singapore) respectively. It supports investments in Hong Kong stocks, US stocks, A-shares (Shanghai, Shenzhen and Hong Kong stock connect), Singapore Stocks, Japan Stocks, UK Stocks, US options, ETFs, Funds, Bonds, Asset Management, Structured Notes, Futures, Crypto, Precious Metals, Gold, and forex. Furthermore, uSMART is equipped with a highly professional research and asset management team that offers asset management, wealth management, securities brokerage, institutional business, LPF services, and investment banking, dedicated to serving ultra-high-net-worth individuals and families, corporations, investment institutions, fund companies, and other brokerage firms with comprehensive asset management solutions.For details please visit: https://hk.usmartglobal.comMedia Enquiries:Carrie Wong+852 9788 4665carriewong@usmart.hk Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
World Premiere of the New Hilux in Asia JCN Newswire

World Premiere of the New Hilux in Asia

Toyota City, Japan, Nov 10, 2025 - (JCN Newswire via SeaPRwire.com) - Toyota Motor Corporation (Toyota) announced that it will globally deploy diverse powertrains, including battery electric vehicles (BEVs) and fuel cell electric vehicles (FCEVs), based on its multi-pathway approach to achieve a carbon-neutral society. On November 10, Toyota held the world premiere of the new Hilux, which includes a new BEV model, at a new vehicle announcement event held by Toyota Motor Asia (TMA)*1 in Bangkok, Thailand. In Asia, Toyota plans to launch sequentially from 2026 onward. For Japan-bound models, where a diesel version is planned, the launch is scheduled for mid-2026*2.Toward Carbon NeutralityToyota is committed to product- and region-centered management with the aim of making ever-better cars. In developing powertrain systems to achieve carbon neutrality, various types of mobility are being introduced as part of Toyota's multi-pathway approach. This approach offers electrified vehicle options tailored to the energy circumstances and varied customer needs in each country and region worldwide.With the new Hilux, Toyota will further accelerate the multi-pathway approach by developing an FCEV model in addition to the diesel and BEV models announced today. The FCEV model is scheduled to be introduced in Europe and Oceania starting in 2028.*1 Toyota's operating company in Asia*2 A special website will be launched today and information will be updated regularly. The special website can be accessed here.The Hilux (BEV model) announced in ThailandThe Hilux (BEV model displayed at the event, Prototype)This model is equipped with a lithium-ion battery with a total electric power of 59.2 kWh*3. Cruising range of 300 km or more*4 is achieved by increasing eAxle efficiency.The battery pack is installed under the floor, making full use of the frame width.High-output eAxles are used in the front and rear, providing maximum system output*5 of 144 kW, and an advanced control system achieves excellent off-road performance.Main Hilux (BEV model, Prototype) specifications for ThailandDriveline4WDLength (mm)5,320Width (mm)1,855Height (mm)1,800Wheelbase (mm)3,085Battery capacity (total electric power) (kWh)*359.2Cruising range (km)*4300 or moreMaximum system output (kW)*5144 *3 Measured in accordance with IEC standard 62660-1*4 NEDC mode value; development target value*5 Output that can be achieved by the system (value calculated by Toyota)Moving forward, Toyota will continue to address customer needs in each region and contribute to carbon neutrality by developing various options while striving to make ever-better cars.The speech by Chief Branding Officer Simon Humphries during the premiere eventSimon HumphriesSawadee Krap-here in Thailand and tuning in from around the world. It is a great pleasure to be back here in Bangkok.I would like to begin by expressing, on behalf of Chairman Akio Toyoda and all at Toyota Motor Corporation, our condolences on the passing of Her Majesty Queen Sirikit, The Queen Mother.Toyota has had a close partnership with Thailand for over 60 years. Since the very beginning, this has been not simply an investment, but a partnership. And that partnership has become a friendship.At Toyota, we talk a lot about our "Best in Town" approach, and Thailand is a living embodiment of that philosophy-the first country in Asia outside of Japan where Toyota produced cars.The seed that was planted more than 60 years ago, has been nurtured by the people of Thailand.Thanks to the strong support of the Thai government, our partners and customers, Thailand has become a hub of production, innovation, and above all, collaboration.What we have achieved here is proof that global success comes from local strength. People in 133 countries around the world now benefit from that the fruits of our partnership. More than 13 million vehicles have been produced here.Our Chairman Akio Toyoda knows the strength of that partnership first hand.It was his time working with the team here in Thailand that helped shape that fundamental approach to leadership. Respect for local culture, respect for the importance of shared decision-making.The vehicle that best represents Akio's connection to Thailand, is the IMV project over 20 years ago.The Hilux story began in 1968 but in 2004, under Akio's leadership as head of the ASIA region, Hilux became part of the IMV series―a truly global platform that symbolized Toyota's Best in Town approach, and our monozukuri philosophy. It was the IMV platform that took Hilux global.As the flagbearer of the IMV platform, there is no vehicle that better represents Thailand's importance to Toyota, than Hilux.We are proud to hear that many people even call Hilux Thailand's national vehicle.At Toyota, we have always believed in "Mobility for All."For us, mobility is about giving people the means to explore, to work, to connect-and to improve their lives. From day one, the Hilux project carried this philosophy: to create vehicles that enrich communities and empower people across every continent.For farmers transporting produce, for families heading out on long trips, for workers building the cities around us, Hilux quickly earned a reputation for quality, durability and reliability.Tough enough for construction sites, safe enough for a family road trip, trusted around the world.The new Hilux we announce today is the 9th generation of this legendary vehicle.With each generation, it has only grown stronger: shaped by roads, by engineers, and most importantly, by the voices of customers everywhere.As the world changed, so too did Hilux.Because Toyota listened. We listened to the miners who needed toughness. We listened to families who wanted more comfort.We listened to fleet owners who cared about fuel economy, and to young adventurers who wanted design and technology that matched their lifestyle.Dependable transportation. Connecting people to opportunity with vehicles that were tough, simple, and built to last...Looking ahead, Toyota is pursuing carbon neutrality not with a single solution, but with a multi-pathway approach.Because the truth is simple: no two regions are the same, and no customer is the same.This extends to the powertrain, the body variations and the customizability...all with the aim of leaving nobody behind.Each generation of Hilux has evolved, but the promise is unchanged: Hilux is a partner for life.Ladies and gentlemen, Chairman Akio Toyoda believes that cars, and car making, should not only be part of society and economic prosperity, but a part of culture.For Akio, Thailand is a "home away from home". On a professional level and a personal level, our partnership has become a friendship.He often says that "we want to give back to Thailand". Over the years, our relationship with Thailand has grown beyond economic exchange, to cultural exchange.As president of the International Sumo Federation, Chairman Toyoda found great pleasure in seeing Thailand recently host the Sumo World Championship, bringing Japan's national sport to Thailand for the first time.Although Akio couldn't attend personally, former Yokozuna sumo wrestler Hakuho Sho visited Bangkok.Hakuho is known as the greatest sumo wrestler of all-time. He dominated the world of Sumo for over a decade, winning a record 45 championships...and he's in the Guiness Book of Records for his total of 1,187 career wins...a feat unmatched in sumo's long history. And that's a history of 1,500 years!As a Toyota ambassador, he also stopped by Toyota Motor Thailand.Akio is a former sportsman himself, and over the years he and Hakuho have become friends through their shared passion for nurturing upcoming generations of athletes.In that spirit of friendship, ladies and gentlemen, I would like to welcome back to Thailand, Hakuho!Hakuho, thank you so much for joining us.Hakuho ShoGood morning Thailand, I was just here in September to expand the Sumo to the world. It is great to be back.When Akio suggested that I come to Thailand for this occasion, I said "of course".Thank you again for inviting me to a global launch of a global car, I wish to expand sumo to the same global stage.Sumo is about purity. It's training not only for physical strength but also for mental strength. I believe promoting sumo will deliver hope to resolve discrimination and prejudice around the world.I am originally from Mongolia. And as a Mongolian representing Japan on the world stage, I feel very close to the people of Thailand representing Japan on the world stage through Toyota.Simon HumphriesAs a British person who has spent two-thirds of my life in Japan, I very much agree with that sentiment!History and cultural exchange...now we are going to take it to the next level with the next generation Hilux.I would now like to invite Hakuho to join me in introducing a car that, like a world-leading Sumo wrestler, is strong, sturdy and focused!Ladies and gentlemen, the new Hilux!"Achieving zero, and adding new value beyond it"As part of efforts to pass our beautiful "Home Planet" to the next generation, Toyota has identified and is helping to solve issues faced by individuals and overall society, which Toyota calls "Achieving Zero," hoping to help reduce the negative impacts caused by these issues to people and the environment to zero. Additionally, Toyota is also looking "Beyond Zero" to create and provide greater value by continuing to diligently seek ways to improve lives and society for the future.About Beyond Zero: https://global.toyota/en/mobility/beyond-zero/Toyota Motor Corporation works to develop and manufacture innovative, safe and high-quality products and services that create happiness by providing mobility for all. We believe that true achievement comes from supporting our customers, partners, employees, and the communities in which we operate. Since our founding over 80 years ago in 1937, we have applied our Guiding Principles in pursuit of a safer, greener and more inclusive society. Today, as we transform into a mobility company developing connected, automated, shared and electrified technologies, we also remain true to our Guiding Principles and many of the United Nations' Sustainable Development Goals to help realize an ever-better world, where everyone is free to move.SDGs Initiatives: https://global.toyota/en/sustainability/sdgs/ Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
MHI Signs EPC Contract for Large-Scale Ammonia and Urea Fertilizer Production Complex for the State Concern Turkmenhimiya JCN Newswire

MHI Signs EPC Contract for Large-Scale Ammonia and Urea Fertilizer Production Complex for the State Concern Turkmenhimiya

TOKYO, Nov 10, 2025 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Heavy Industries, Ltd. (MHI) has signed an EPC (Engineering, Procurement and Construction) contract with SC Turkmenhimiya, the state-owned chemical company of Turkmenistan, for the construction of a large-scale ammonia and urea fertilizer production complex. The contract was concluded in partnership with Gap Insaat Yatirim ve Dis Ticaret A.S. (GAP), a leading Turkish contractor. The groundbreaking ceremony was held on November 2, 2025, attended by the President of Turkmenistan, His Excellency Serdar Berdimuhamedov. The plant is scheduled to begin operations in 2030.The project involves the construction of the largest ammonia and urea fertilizer production plant in Turkmenistan. Located on the coastline of the Caspian Sea at Kiyanly in the Balkan province in northwestern Turkmenistan, the project covers basic and detailed design, equipment procurement, construction works, and commissioning of the plant. In addition to the ammonia and urea fertilizer production plant with its associated utilities and offsite facilities, the scope also includes peripheral infrastructure such as temporary piers and product shipment facilities. The planned daily production capacity is 2,000 metric tons of ammonia and 3,500 metric tons of urea. MHI will be responsible for the basic and detailed design, procurement, and commissioning of the ammonia and urea fertilizer plant, and will collaborate closely with GAP and Mitsubishi Corporation to execute the project.Turkmenistan is one of the world's leading countries in natural gas reserves and has prioritized the production of high value-added products using its abundant natural resources and the diversification of export products as key pillars of its national strategy. The fertilizers produced at this plant are expected to greatly contribute to the country's economic growth and enhancement of international competitiveness. Additionally, the plant will be equipped with a CO2 capture facility applying MHI's proprietary "Advanced KM CDR Process™", developed jointly with Kansai Electric Power Co., Inc. This facility will improve plant efficiency and reduce environmental impact, thereby contributing to the realization of a sustainable society.MHI has delivered numerous fertilizer production facilities worldwide since its first plant in 1958. In Turkmenistan, MHI delivered a plant in Garabogaz on the Caspian Sea coast in 2018 in partnership with Mitsubishi Corporation and GAP. This plant has maintained stable operations since its commissioning. This contract award is based on that proven track record as well as a high evaluation of MHI's CO2 capture technology.MHI will continue to strengthen its presence in the global fertilizer plant market and contribute to the world by providing safe and reliable production facilities.About MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
Mitsubishi Heavy Industries Announces Order Intake, Revenue, and Profit Growth in Strong 1H FY2025, Raises Full-Year Order Intake and Revenue Guidance JCN Newswire

Mitsubishi Heavy Industries Announces Order Intake, Revenue, and Profit Growth in Strong 1H FY2025, Raises Full-Year Order Intake and Revenue Guidance

TOKYO, Nov 7, 2025 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Heavy Industries, Ltd. (MHI, TSE Code: 7011) announced that order intake increased 8.5% year-on-year to ¥3,314.7 billion in the half year ended September 30, 2025. Revenue rose 7.3% year-on-year to ¥2,113.7 billion, resulting in profit from business activities (business profit) of ¥171.5 billion, a 2.1% increase over the previous fiscal year, which represented a profit margin of 8.1%. Profit attributable to owners of parent (net income) was ¥114.9 billion, an increase of 7.3% year-on-year, with a profit margin of 5.4%. EBITDA was ¥229.6 billion, a 2.5% increase over 1H FY2024, with an EBITDA margin of 10.9%.(billion yen, except where otherwise stated)1H FY2025 Financial Results1H FY2024 (Note)1H FY2025YoYYoY%Order Intake3,054.63,314.7+260.0+8.5%Revenue1,969.22,113.7+144.4+7.3%Profit from Business ActivitiesProfit Margin168.08.5%171.58.1%+3.4-0.4 pts+2.1%-Profit Attributable to Owners of ParentProfit Margin107.15.4%114.95.4%+7.7±0.0 pts+7.3%-EBITDAEBITDA Margin224.111.4%229.610.9%+5.5-0.5 pts+2.5%-FCF-85.7151.0+236.8- - 1H FY2024 results have been retroactively adjusted to reflect the planned sale of Mitsubishi Logisnext (ML) shares. For more information on the ML sale, please refer to the following press releases published on September 30, 2025:1) ML Sale Announcement 2) Revision of FY2025 Earnings Forecast (billion yen, except where otherwise stated)1H FY2025 Financial Results by SegmentOrder IntakeRevenueBusiness Profit1HFY2025YoY (Note)1HFY2025YoY (Note)1HFY2025YoY (Note)Energy Systems (Energy)1,981.2+674.5871.0+38.880.7-22.4Plants & Infrastructure Systems (P&I)490.6-108.7415.9+36.744.6+16.4Logistics, Thermal & Drive Systems (LT&D)292.8-35.9282.4-21.47.6+1.3Aircraft, Defense & Space (ADS)545.0-257.0538.8+107.160.3+16.3Others, Corporate & Eliminations (OC&E)4.9-12.65.4-16.7-21.8-8.3Total3,314.7+260.02,113.7+144.4171.5+3.4 - 1H FY2024 results on which YoY figures are based have been retroactively adjusted to reflect the planned sale of ML shares. In Energy, order intake increased by ¥674.5 billion YoY mainly due to continued strong demand in Gas Turbine Combined Cycle (GTCC). Contracts for 23 large frame gas turbine units—up 14 units YoY—were concluded during 1H, the majority of which were from customers in North America and Asia. Revenue increased by ¥38.8 billion YoY; the largest gains were seen in GTCC, which continued to execute its sizeable backlog. Segment business profit decreased by ¥22.4 billion YoY due to one-time charges in Steam Power, which offset strong performance in GTCC from both higher revenue and margins.In P&I, order intake decreased by ¥108.7 billion YoY due to the absence of large orders booked in the previous fiscal year in Metals Machinery and Machinery Systems. Revenue grew by ¥36.7 billion YoY. Improved margins in Metals Machinery and Machinery Systems helped to raise segment business profit by ¥16.4 billion YoY.In LT&D, revenue decreased by ¥21.4 billion YoY due to a decline in units sold in Turbochargers and Heating, Ventilation & Air Conditioning (HVAC) and foreign exchange impact in HVAC. Steady performance in Engines on the back of strong demand in Asia, combined with the rebound from one-time charges associated with a supply chain disruption in Turbochargers during the previous fiscal year, resulted in a ¥1.3 billion YoY increase in segment business profit.In ADS, order intake decreased by ¥257.0 billion YoY due to a high base effect from large orders booked in Defense & Space during the previous fiscal year. Revenue increased by ¥107.1 billion YoY, mainly in Defense & Space, where steady progress in backlog execution continued. Increased revenue and higher margins in Defense & Space and Commercial Aviation served to increase segment business profit by ¥16.3 billion YoY.FY2025 Earnings ForecastMHI revised its guidance for the period ending March 31, 2026, increasing the forecasts for order intake and revenue over the previous announcement made on September 30, 2025, based on stronger-than-anticipated performance during 1H. The full-year dividend forecast of 24 yen per share was unchanged from the announcement made on August 5, 2025. (billion yen, except where otherwise stated)FY2025 Earnings ForecastFY2024Actual (Note)FY2025Forecast(9/30 Announcement)FY2025Forecast(Revised)Revised vs.PreviousOrder Intake6,405.15,250.06,100.0+850.0Revenue4,361.14,750.04,800.0+50.0Profit from Business ActivitiesProfit Margin354.98.1%390.08.2%390.08.1%--0.1 ptsProfit Attributable to Owners of ParentProfit Margin245.45.6%230.04.8%230.04.8%--ROE10.7%-10%-EBITDAEBITDA Margin469.910.8%--510.010.6%--FCF342.7-0.0-Dividends23 yen-24 yen- - FY2024 results have been retroactively adjusted to reflect the planned sale of ML shares. (billion yen, except where otherwise stated)FY2025 Earnings Forecast by SegmentOrder IntakeRevenueBusiness ProfitPreviousRevisedPreviousRevisedPreviousRevisedEnergy2,200.03,200.01,850.02,000.0240.0240.0P&I900.0900.0850.0850.060.070.0LT&D750.0600.0750.0600.040.020.0ADS1,400.01,400.01,350.01,350.0140.0140.0OC&E0.00.0-50.00.0-90.0-80.0Total5,250.06,100.04,750.04,800.0390.0390.0 CFO Message"The strong growth MHI achieved in the first quarter continued through the first half of this fiscal year, with order intake, revenue, and business profit all up year-on-year, and net income marking an all-time high for the company," MHI Chief Financial Officer Hiroshi Nishio commented. Nishio continued, "GTCC was our star performer in terms of order intake, booking 23 large frame gas turbine units across North America and Asia. We continue to see high demand for gas turbines particularly in the U.S., where new electricity demand from the data center buildout and other factors are driving capital expenditures at our utility customers. Revenue was up especially in GTCC and Defense & Space, which made excellent progress executing on their sizeable backlogs. Business profit growth was small, but the fact that we were able to beat last year's figure—despite one-time expenses recognized in Steam Power—reflects the high normalized margins we are achieving today in GTCC and some other businesses.""Based on our results through the first half," Nishio went on, "we have increased our order intake and revenue forecasts due to better-than-expected results in Energy Systems, mainly GTCC. We have maintained the business profit guidance announced on September 30, with continued strength from growing revenue and improving margins in other businesses compensating for one-time expenses in Energy Systems in excess of the initial 20-billion-yen risk buffer and weakness in the remainder of the Logistics, Thermal & Drive Systems segment. MHI's strong performance despite growing uncertainty in global markets is a testament to our resilience as a company, which has been made possible in part by our continued efforts to evolve our portfolio of businesses. We appreciate the continued support of our shareholders and other stakeholders as we work to meet our full-year commitments during the second half of the fiscal year."Attachment 1: 1H FY2025 Financial ResultsFinancial Results (465 KB)Attachment 2: Presentation Materials of Financial ResultsPresentation Materials (508 KB)Downloadable PDF of this press releasePress Release (164 KB)Forward Looking Statements:Forecasts regarding future performance outlined in these materials are based on judgments made in accordance with information available at the time they were prepared. As such, these projections include risk and uncertainty. Investors are recommended not to depend solely on these projections when making investment decisions. Actual results may vary significantly from these projections due to a number of factors, including, but not limited to, economic trends affecting the Company's operating environment, fluctuations in the value of the Japanese yen to the U.S. dollar and other foreign currencies, and trends in Japan's stock markets. The results projected here should not be construed in any way as a guarantee by the Company.In response to U.S. tariff policy, the Company is pursuing mitigation strategies focused on cost passthroughs. As of the date of this release, the Company expects any impact on performance to be limited in nature.About MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
MHI Reaches a Basic Agreement with J-POWER on the Transfer of its Domestic Onshore Wind Power Business JCN Newswire

MHI Reaches a Basic Agreement with J-POWER on the Transfer of its Domestic Onshore Wind Power Business

TOKYO, Nov 7, 2025 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Heavy Industries, Ltd. (MHI) has reached a basic agreement with Electric Power Development Co., Ltd. (J-POWER) to commence discussions on the transfer of MHI's domestic onshore wind power business (the "Subject Business") to J-POWER. Upon reaching mutual agreement on the necessary conditions for the transfer, both parties will execute a definitive agreement, aiming to complete the transfer by April 1, 2026.Since initiating the manufacturing of large-scale wind turbines domestically in the 1980s, MHI has accumulated more than 40 years of extensive knowledge and expertise in wind turbine technology. To date, MHI has delivered over 4,200 turbines to 11 countries worldwide, primarily in North America and Japan, and has continuously provided after-sales services. Through this business transfer, MHI aims to fully leverage its specialized expertise across a broader range of fields.J-POWER is committed to balancing stable domestic power supply with addressing climate change by actively developing its wind power business. The J-POWER Group contributes to stable electricity supply and is also pursuing carbon neutrality, as outlined in the J-POWER "BLUE MISSION 2050" announced in February 2021.(Note) Wind power has been a core focus for J-POWER since it was among the first in Japan to operate a large-scale commercial wind farm in 2000, and it currently holds the second-largest domestic market share in wind power generation facilities.The transfer of the Subject Business will strengthen and further expand J-POWER's foundation as a wind power developer by integrating MHI's accumulated wind power expertise. This collaboration is expected to accelerate the future expansion of J-POWER's wind power business and related services, leading to further growth. MHI is convinced that this will not only provide customers with greater value but also offer new opportunities for growth and development to employees engaged in this business.MHI Group will continue to optimize its business organization in line with the policy of strengthening portfolio management set out in the 2024 Medium-Term Business Plan.For more information, please visit: https://www.jpower.co.jp/english/bluemission2050/Notice Regarding the Conclusion of a Basic Agreement Concerning the Transfer of Business to a Subsidiary via Company Split (Simplified Absorption-type Split) and the Transfer of Shares in Said Subsidiary (272KB)About MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More
JFCR and NEC Confirm Research Results for Developing Individualized Neoantigen Cancer Vaccines Using Whole-Genome Data JCN Newswire

JFCR and NEC Confirm Research Results for Developing Individualized Neoantigen Cancer Vaccines Using Whole-Genome Data

TOKYO, Nov 7, 2025 - (JCN Newswire via SeaPRwire.com) - The Japan Foundation of Cancer Research (JFCR) and NEC Corporation (NEC; TSE: 6701) have confirmed research results supporting the development of a novel personalized neoantigen cancer vaccine using whole-genome data (*1). Analysis utilizing NEC's proprietary AI technology from breast cancer and soft tissue sarcoma has successfully enabled the prediction of numerous cancer-specific antigens (cryptic antigens, *2) originating from dark genomes—regions of the genome whose function and role remain largely unexplored—in addition to conventional neoantigens (*3). Developing vaccines using these antigens could potentially offer new treatment options for cancers that have been difficult to treat until now.Both organizations will present these findings at the annual meeting of the Society for Immunotherapy of Cancer (SITC), held in National Harbor, Maryland, USA, from Wednesday, November 5 to Sunday, November 9, 2025.This joint research project will be carried out as part of the Japan Agency for Medical Research and Development (AMED)’s "Action Plan for Whole-Genome Analysis for Cancer and Rare/Intractable Diseases," within the research initiative on the "Demonstration of the Clinical Utility of Cancer Whole-Genome Analysis and Research on Establishing Systems for Patient Benefit".In recent years, personalized medicine—aiming for more effective and optimal treatments based on each patient's genomic information and gene expression profiles—has garnered significant attention. Among these approaches, immunotherapy using personalized cancer vaccines that target neoantigens specific to each patient's cancer cells is especially promising for practical application due to its potential for high therapeutic efficacy and reduced side effects. In Japan, efforts to promote research and drug discovery utilizing whole-genome analysis data are accelerating, as demonstrated by the Ministry of Health, Labour and Welfare's formulation of the "Action Plan for Whole Genome Analysis 2022" (*4). Against this backdrop, the Cancer Institute and NEC have been collaborating since 2024 on the development of a novel personalized neoantigen cancer vaccine utilizing whole-genome analysis data.The prevalence of neoantigens is known to vary across cancer types. In this study, the Cancer Institute and NEC analyzed whole-genome data from breast cancer and soft tissue sarcoma, which are considered to have relatively low neoantigen emergence rates, utilizing NEC's proprietary AI technology. This study sought to demonstrate that integration of whole genome data allows the identification of relevant immunogenic targets, even in patients with cancer associated with a low number of canonical antigens.The collaborative research successfully predicted the presence of numerous non-canonical antigens, in addition to previously known classes of antigen targets. Developing vaccines utilizing these findings is expected to open new therapeutic approaches for cancer types that have traditionally been considered difficult to treat with personalized neoantigen cancer vaccines."We are delighted to share the findings of our basic research aimed at developing next-generation personalized cancer vaccines. This work was conducted under an AMED research program based on the Action Plan for Whole-Genome Analysis 2022 (Ministry of Health, Labour and Welfare). By integrating whole-genome data with NEC’s proprietary AI technology, we have revealed the potential presence of diverse cancer-specific antigens, known as cryptic antigens, derived from the dark genome even in cancer types previously considered to have limited neoantigen expression. Moving forward, we will continue to evaluate the immunogenicity of these antigens and advance the development of personalized cancer vaccines to realize the next generation of cancer immunotherapy."Tetsuo Noda, M.D., Ph.D., Advisor, Atsushi Ohtsu, M.D., Ph.D., Research Director, Japanese Foundation for Cancer Research"We are pleased to share our research findings on cryptic antigens, developed in collaboration with JFCR. This work, which utilizes whole-genome data and NEC's proprietary AI technology, will be presented at the SITC Annual Meeting as part of a project supported by AMED. Going forward, the NEC Group remains committed to advancing our mission of delivering innovative AI-powered healthcare solutions to patients around the world."Motoo Nishihara, Executive Officer, Corporate EVP and CTO, NECPresentation DetailsAbstract Number: 162Title: A Whole-Genome-Informed Pipeline for Neoantigen Discovery in Solid Tumors: Integrating SNV, Splice Variant, and Exon-Transposon Junction Analysis to Enable Personalized Cancer VaccinesPresenters: Jun MasudaAuthors: Jun Masuda1, Kazuma Kiyotani2, Kazuhide Onoguchi3, Per Brattås4, Hugues Fontenelle4, Angelina Sverchkova4, Sumana Kalyanasundaram4, Pierre Machart5, Yuki Tanaka3, Daiki Miura3, Noboru Nagata3, Koji Yoshino1, Mingyon Mun1, Yasuji Miyakita1, Hiroki Mitani1, Souya Nunobe1, Yu Takahashi1, Hiroyuki Kanao1, Takashi Akiyoshi1, Keisuke Ae1, Kengo Takeuchi1, Junji Yonese1, Masayuki Watanabe1, Seiichi Mori6, Seiya Imoto7, Ippei Fukada1, Shunji Takahashi1, Takayuki Ueno1, Noboru Yamamoto8, Kaïdre Bendjama4, and Shigehisa Kitano1Affiliation: 1) The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan. 2) National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan. 3) NEC Corporation, Tokyo, Japan. 4) NEC OncoImmunity AS, Oslo, Norway. 5) NEC Laboratories Europe GmbH, Heidelberg, Germany. 6) Japanese Foundation for Cancer Research, Tokyo, Japan. 7) The Institute of Medical Science, the University of Tokyo, Tokyo, Japan. 8) National Cancer Center Hospital, Tokyo, Japan.Release Date: November 8, 2025(*1) Genome analysis includes: 1.methods targeting only specific genomic regions called coding regions, and 2.methods targeting both coding and non-coding regions. In this study, whole-genome data analysis (corresponding to 2.) was performed on samples provided by cancer patients.(*2) A type of neoantigen; a cancer antigen originating from non-coding regions of the genome that do not encode proteins.(*3) Refers to "cancer-specific antigens (markers)" newly generated by genetic mutations in cancer cells. Since they are absent in healthy cells and appear only in cancer cells, the immune system can recognize them as foreign substances and target them for attack.(*4) A plan formulated as a national strategy primarily to advance genome analysis in the medical field. Its objectives include developing new diagnostics and treatments for cancers and rare/intractable diseases, as well as promoting the realization of personalized medicine.About Japanese Foundation for Cancer ResearchJapanese Foundation for Cancer Research (JFCR) was founded in 1908 as the first organization in Japan specialized for study and control of cancer. JFCR has been playing a leading role in cancer research and treatment for a long time. We have three research centers and a hospital, which are "Cancer Institute" for basic cancer research, "Cancer Chemotherapy Center" for drug development, "Cancer Precision Medicine Center" (CPM Center) and "Cancer Institute Hospital of JFCR" for development of novel cancer treatments. These centers and a hospital are working together to achieve our common goal which is cancer control.About NECThe NEC Group leverages technology to create social value and promote a more sustainable world where everyone has the chance to reach their full potential. NEC Corporation was established in 1899. Today, the NEC Group's approximately 110,000 employees utilize world-leading AI, security, and communications technologies to solve the most pressing needs of customers and society. For more information, please visit https://www.nec.com, and follow us on Instagram, Facebook, and LinkedIn. Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
More