Day: 29 7 月, 2025

HONG KONG, July 29, 2025 - (ACN Newswire via SeaPRwire.com) - July 25, Guotai Junan International Holdings Limited (“GTJAI” or the “Company”, stock code: 1788.HK), a company of Guotai Haitong Group, is pleased to announce that while actively saving energy and reducing emissions，it has successfully offset its Scope 1 and Scope 2 carbon emissions totaling 609.29 tons of carbon dioxide equivalent for the year 2024 by subscribing to the carbon credits issued under the international Verified Carbon Standard (VCS). This marks the third consecutive year that GTJAI has achieved “carbon neutrality” at the operational level, demonstrating the Company's leading practice and commitment to green operation.The carbon credits come from “Guoluo Grassland Sustainable Management Project” located in Guoluo Tibetan Autonomous Prefecture, Qinghai Province, China. It is dedicated to the restoration of degraded grassland ecosystems, based on the holistic nature of the ecosystems, in line with the concept of ecological civilization construction, and to effectively respond to the challenges of climate change. The project is also the first grassland carbon project in China receiving both VCS certification and the Climate, Community and Biodiversity Standards (CCB) - CCB-Biodiversity Gold Level certification.In recent years, GTJAI has been continuously reducing its operational carbon footprint through systematic energy saving and emission reduction initiatives, which is the core support for the achievement of “carbon neutrality”, including vigorously implementing energy-saving renovation of office space, deepening digitalization and paperless transformation, and implementing stringent waste management (100% safe recycling of hazardous waste by 2024). Solid internal emission reduction efforts, combined with carbon offsetting through high-quality carbon credits, enabled the Company to achieve “carbon neutrality” at the operational level.Adhering to the core philosophy of “finance for the country, finance for the people, finance for the good”, GTJAI has always placed sustainable development at the core of its corporate strategy. The Company is committed to supporting the real economy through financial services while facilitating the green transformation of its corporate clients. In 2024, the Company successfully completed 90 sustainable finance projects covering green bonds, sustainable bonds and green sector IPOs with a total issuance volume of HK$179.8 billion, significantly broadening the financing pipeline for the green industry. Meanwhile, the private equity sector is actively engaged in the sustainability sector, with more than half of its investments focusing on ESG-related industries.Looking ahead, GTJAI will deepen the level of ESG governance, fully integrate ESG factors into its operations and management processes, further leverage its professional strengths and enhance the level of green financial services capabilities. Through innovative products and services, GTJAI will proactively contribute to the realization of the country's “dual carbon” goal and promote the high-quality development of the economy and society.About GTJAIGuotai Junan International (“GTJAI”, Stock Code: 1788.HK), a company of Guotai Haitong Group, is the market leader and first mover for internationalization of Chinese Securities Company as well as the first Chinese securities broker listed on the Main Board of The Hong Kong Stock Exchange through initial public offering. Based in Hong Kong with subsidiaries in Singapore, Vietnam and Macau, GTJAI’s business covers major markets around the world, offering high-quality and diversified comprehensive financial services for clients' overseas asset allocation. Core business includes brokerage, corporate finance, asset management, loans and financing, financial products, which cover three dimensions including individual finance (wealth management), institutional finance (institutional investor services and corporate finance) and investment management. GTJAI has been assigned “Baa2” and “BBB+” long term issuer rating from Moody and Standard & Poor respectively, as well as an MSCI ESG “A” rating, Wind ESG “A” rating and SynTao Green Finance “A” rating in ESG. Additionally, its S&P Global ESG score leads 84% of its global peers. The controlling shareholder, Guotai Haitong Securities (Stock Code: 601211.SH; 2611.HK), is the comprehensive financial provider with a long-term, sustainable and overall leading position in the China’s capital markets. For more information about GTJAI, please visit https://www.gtjai.com Copyright 2025 ACN Newswire via SeaPRwire.com.

- The HKTDC continues to help SMEs seize digital trade opportunities by co-hosting with the ICC DSI a masterclass on technologies such as electronic bills of lading and blockchain. More than 200 SMEs took part.- Prof Frederick Ma, Chairman of the HKTDC, emphasised that Hong Kong is actively developing its digital trade ecosystem, with a focus on innovation, efficiency and international collaboration, to consolidate its competitive advantages. As digital trade becomes more common, the HKTDC will ensure Hong Kong businesses continue to thrive and enhance the city’s role as a leading supply chain hub.- Pamela Mar, Managing Director of ICC DSI, noted that by aligning its finance, trade and logistics sectors with global digital trade standards, Hong Kong can remain competitive and resilient on the world stage and is well-positioned to spearhead Asia’s digital-trade development.- Andy Lam, Deputy Secretary for Commerce and Economic Development of the HKSAR Government, said that the Government is making reference to the Model Law on Electronic Transferable Records and is considering legislative amendments to remove the legal hurdles in the digitalisation of trade documents. The target is to submit the relevant legislative proposal to the Legislative Council next year to help industry develop technical solutions based on their actual needs.HONG KONG, July 28, 2025 - (ACN Newswire via SeaPRwire.com) - Digitalisation is reshaping the global economy, and companies must embrace digital transformation to capitalise on new opportunities. The 2025-26 Budget announced that the Hong Kong Special Administrative Region (HKSAR) Government would make reference to the Model Law on Electronic Transferable Records (MLETR) advocated by the United Nations Commission on International Trade Law (UNCITRAL) and consider legislative amendments to facilitate digitalisation of trade documents. The legislative proposal will be submitted to the Legislative Council next year. The MLETR is a global standard advocated by the UNCITRAL to provide a legal framework for electronic trade documents. Aligning local legislation with standards of the MLETR is a major endeavour in promoting trade digitalisation. In line with these efforts, the Hong Kong Trade Development Council (HKTDC) and the International Chamber of Commerce Digital Standards Initiative (ICC DSI) co-hosted the “Digital Trade Masterclass” at the Hong Kong Convention and Exhibition Centre to examine the MLETR’s potential impact on Hong Kong’s cross-border trade. Industry experts shared practical insights on digital transformation, helping equip businesses with the information they need to enhance their high value-added service capabilities. More than 200 SMEs participated in the event.As an international financial and trading centre and a leading re-export hub, Hong Kong is able to capitalise on its unique advantages to reinforce connectivity, serving as a bridge linking the mainland and global markets. It provides high-standard professional services, robust financial infrastructure and an innovative environment for international trade. The HKTDC works closely with the HKSAR Government to highlight the city’s strength in delivering high value-added services across the trade supply chain.Speaking at the event, Prof Frederick Ma, Chairman of the HKTDC, said that with the changing trade landscape, there was no better time to reinforce Hong Kong’s competitive advantages. “Hong Kong is actively developing its digital trade ecosystem, with a focus on innovation, efficiency and international collaboration, to consolidate its competitive advantages. As digital trade becomes more common, we are committed to making sure Hong Kong businesses continue to thrive. It is also a great opportunity to reinforce our city’s role as a leading supply chain hub. The HKTDC is dedicated to helping businesses leverage innovative technologies to equip businesses to be future-ready. Our Asian Logistics, Maritime and Aviation Conference (ALMAC) examines trends in global trade and supply chains, innovation and digitalisation, while our support programmes, including Transformation Sandbox, help enterprises scale up their capabilities in key areas, including digital transformation and supply chain solutions, to empower SMEs and start-ups to benefit from digital trade.”Pamela Mar, Managing Director of the ICC DSI, believes Hong Kong, as an international trade and logistics hub already aligned with global standards, will lead Asia’s future digital trade development by remaining competitive and resilient amid a shifting global landscape. “Finance, trade and logistics make up over 45 % of Hong Kong’s economy, so accelerating digitalisation in these sectors will have a positive economy-wide impact.”, said Pamela Mar. “Hong Kong is well-positioned to become a leader in this space by aligning global standards and building on its strength as a trusted hub. The adoption of MLETR is a vital step, providing legal certainty for electronic documents like bills of lading, while streamlining processes and enhancing traceability. But legal reform is only the beginning — even greater gains lie in the private sector stepping up its digital transformation, which can be enhanced by Web3 technologies.”Andy Lam, Deputy Secretary for Commerce and Economic Development of the HKSAR Government, said, “The HKSAR Government is committed to fostering an efficient business environment and maintaining the international competitiveness of Hong Kong. Facilitating the digitalisation of trade documents is part of this strategy. We anticipate that the industry would actively provide feedback and allow the Government to formulate a legal framework that is in line with the needs of the industry, on which basis the industry may propose different technical solutions. On the other hand, the Government is also pressing ahead with Phase 3 of the Trade Single Window, which will not only facilitate the industry in their submission of business-to-government trade documents such as import and export declarations, but will also connect with the Hong Kong Monetary Authority (HKMA)'s Commercial Data Interchange (CDI) to facilitate banks in accessing relevant data to process trade financing.”Industry experts discuss challenges in trade digital transformationAccelerating digital transformation across every link of the supply chain introduces unique challenges. At the Masterclass, the conference brought together specialists in digital trade finance, electronic bills of lading, digital freight and logistics, and digital retail supply chain management to share their practical experience and insights working on digital transformation.Kenise Sin, Senior Data Analyst in the Financial Infrastructure Department at the HKMA, explained: “SMEs’ access to trade finance has long been hindered by different pain points in the process. For instance, the heavy reliance on paper-based documents has led to inefficiencies and difficulties in tracking and verifying the transactions.” She added that HKMA aims to formulate a digitalisation roadmap for sea, road and air transportation cargo data by the end of this year, integrating cargo data sources across jurisdictions with the HKMA’s CDI, to enhance data sharing. In the coming two years, the HKMA will also work with the Airport Authority Hong Kong, the Transport and Logistics Bureau as well as pilot banks to leverage cargo data and CDI to improve digital trade finance.Erik Kwok, Head of Technology and Operations at Air8 — which develops a supply chain finance platform for cross-border trade — echoed these concerns: “Many small to medium-sized exporters struggle to secure funding due to inadequate data for credit assessments, hindering their ability to compete globally. These obstacles are compounded by insufficient support for risk management strategies, leaving SMEs vulnerable in a rapidly evolving market.”Another guest speaker, Candy Chan, Product Manager at IQAX, outlined how digitalising bills of lading can save both time and costs, boosting the efficiency of the entire trade ecosystem. She said many banks, freight forwarders, and customs systems still operate on fragmented digital platforms and lack interoperability. Blockchain, she argued, can bridge these silos: “Each trading partner has unique operational needs when adopting blockchain networks in digital platforms. In cross-border trade, trading and shipping documents are exchanged, and digitalised documents within a blockchain network can solve trust issues within and across networks, backed by MLETR.”Photo download: http://bit.ly/4lNB4t9Prof Frederick Ma, Chairman of the HKTDC attended the Digital Trade Masterclass and delivered the opening remarks on 28 July.(From left) Andy Lam, Deputy Secretary for Commerce and Economic Development, HKSAR Government; Prof Frederick Ma, Chairman of the HKTDC; and Pamela Mar, Managing Director, ICC DSI.Industry experts shared insights and challenges on digital transformation. Picture shows guest speakers from the Digital Trade Masterclass with the officiating guests.(From left) Kenise Sin, Senior Data Analyst, Financial Infrastructure Department, HKMA; Jack Lee, Chief Operating Officer, GS1 Hong Kong; Bertrand Chen, Chief Executive Officer, Global Shipping Business Network; Andy Lam, Deputy Secretary for Commerce and Economic Development, HKSAR Government; Prof Frederick Ma, Chairman of the HKTDC; Pamela Mar, Managing Director, ICC DSI; Ivy Tse, Co-Chief Executive Officer & Co-founder, FreightAmigo; Erik Kwok, Head of Technology and Operations, Air8; and Candy Chan, Product Manager, IQAX.Over 200 SMEs attended the Digital Trade Masterclass, reflecting strong interest.Media enquiriesPlease contact the HKTDC’s Communications & Public Affairs Department:Johnny TsuiTel: (852) 2584 4395Email: johnny.cy.tsui@hktdc.orgWinnie KanTel: (852) 2584 4055Email: winnie.wy.kan@hktdc.orgAgnes WatTel: (852) 2584 4554Email: agnes.ky.wat@hktdc.orgHKTDC Media Room: http://mediaroom.hktdc.comAbout HKTDCThe Hong Kong Trade Development Council (HKTDC) is a statutory body established in 1966 to promote, assist and develop Hong Kong's trade. With over 50 offices globally, including 13 in Mainland China, the HKTDC promotes Hong Kong as a two-way global investment and business hub. The HKTDC organises international exhibitions, conferences and business missions to create business opportunities for companies, particularly small and medium-sized enterprises (SMEs), in the mainland and international markets. The HKTDC also provides up-to-date market insights and product information via research reports and digital news channels. For more information, please visit:www.hktdc.com/aboutus. Copyright 2025 ACN Newswire via SeaPRwire.com.

SHANGHAI July 28, 2025 - (ACN Newswire via SeaPRwire.com) - 26th July 2025, CITIC Telecom International Holdings Limited (“CITIC Telecom”, SEHK:1883), Asia-Pacific leading multinational Internet-oriented telecommunications enterprise, has joined hands with its subsidiaries including Companhia de Telecomunicações de Macau, S.A.R.L. (“CTM”), CITIC Telecom CPC and China Entercom to exhibit at 2025 WAIC (World AI Conference) for four years in a row.The theme of this year's conference is “Global Solidarity in the AI Era”. In tune with the zeitgeist and guided by CITIC Group’s philosophy, “CITIC, Your Trusted Partner for Going Global and Coming to China”, CITIC Telecom focuses on the strategic direction of “AI+ Connect for Global Reach”. At the WAIC 2025, a compelling display of breakthroughs were showcased, including empowering intelligent business upgrades, enhancing connectivity in digital economies, reinforcing the dual strategies of “Going global” and “Coming to China” market flows, and integrating AI more deeply into real-world industry scenarios.CITIC Telecom continues to play a vital bridging role by actively engaging in the global technology ecosystem enabling Chinese enterprises to pursue “Going Global” strategies while accelerating international enterprises in “Coming to China”, fueling the growth of intelligent technologies.Smart CITIC: Creating Possibilities TogetherCITIC Group participated prominently in this year’s WAIC under the theme “Smart CITIC: Creating Possibilities Together”. Leveraging its integrated strengths in “Technology, Industry & Finance”, the Group showcased a wide range of innovative AI applications and industry-specific AI solutions across technological innovations, emerging industries, financial empowerment, and internationalization. As a key component and strategic pillar of CITIC’s new consumption segment, CITIC Telecom significantly contributed to the “Technology Innovation” and “Internationalization” zones. With close collaboration among its subsidiaries, the exhibit demonstrated its robust foundational tech capabilities, industrial empowerment and ecosystem synergy. It has further unlocked high-quality AI-driven growth, providing CITIC’s intelligence and smart solutions to enhance digitization in China and connect global digital economies. Additionally, a series of on-site “CITIC AI+ Practice Sharing” sessions offered valuable insights into the practical applications and commercial potential of its innovations. “AI+ Connect” for Global Reach: Powering the Next Engine of High-Quality DevelopmentAmidst rapid global digital growth, CITIC Telecom, an important cornerstone of CITIC Group’s international business, is actively embracing China’s “AI+” and high-standard opening-up strategies. It also focuses on fostering a globally interconnected digital ecosystem, deepening the two-way pathways for “Going global” and “Coming to China”, and contributing to a more open, trusted, and mutually beneficial global digital landscape.To realize this strategic vision, CITIC Telecom has established a robust global presence across five continents, comprising nearly 170 Points of Presence, 21 Cloud Service Centers, over 30 Data Centers, and three 24x7 Security Operations Centers (SOCs). These resources and infrastructure support highly responsive, global coverage, agile, digital and intelligent cloud-network-security services. Therefore, it not only provides cybersecurity protection and intelligent connectivity for both central state-owned enterprises and Chinese enterprises going global, but also delivers fast and reliable localized services to multinational corporations, positioning CITIC Telecom as a vital bridge connecting global and local markets, industries and technologies.To further its localization strategy and capability, CITIC Telecom has enhanced regional collaboration through its subsidiaries. ACCLIVIS, operating extensively across ASEAN markets, has accelerated AI, cloud security and cybersecurity deployments in critical sectors such as healthcare and manufacturing, which has infused the Southbound Corridor with sustained innovation momentum. In Greater Bay Area, CTM plays a pivotal role in the “Digital Macau” initiative targeting focus on enabling the moderate economic diversification of Macau, promote smart government, smart campus, smart transformation of various fields. Harnessing the convergence of AI and telecom technologies, it has become a powerful digital and intelligent engine driving Macau’s high-quality development.CITIC Telecom has empowered over 3,000 Chinese and international enterprises in their cross-border development, serving more than 40,000 local clients worldwide, including over 200 Fortune Global 500 enterprises. This highlights the leap from vision to execution in its global strategy, forging partnerships to shape an interconnected digital future.Harnessing Technology: Empowering the Future of “AI+ Connect”In constructing a globally interconnected digital ecosystem, CITIC Telecom is fortifying its innovation foundations to support the next-generation digital framework for enterprises. Leveraging its extensive technological expertise and innovative R&D framework, it is exploring key areas such as AI+ Big data, AI+ Networking, and AI+ Large Model applications, continuously launching scalable, deployable solutions.In the field of AI data governance, AI Databank integrates Big Data, AI, Large Language models (LLMs) and generative AI to create a unified data platform that eliminates silos and enables seamless cross-system integration. Its innovative AI data governance technology has gained widespread adoption across industries and earned the Silver Medal at the 50th International Exhibition of Inventions Geneva in 2025, highlighting CITIC Telecom's excellence in AI research and innovation.In the realm of network services, the “AI Roaming Data Acceleration Pack” project significantly enhances global data transmission efficiency and stability for multinational enterprises by optimizing routing paths and network nodes. By integrating cutting-edge intelligent technologies with the GSMA Open Gateway standards, this solution has been successfully implemented in smart tourism across Hong Kong and Macau. Its innovative approach also earned the Third Prize in the “Open Gateway Global Use Case Innovation Challenge”.In the area of smart living, CITIC Telecom featured CTM’s pioneering “Smart City” project and its 10 Gigabit network infrastructure development in Macau. Powered by a dual-engine approach combining F5G-A and 5G-A technologies, CTM has built Macau’s first “10 Gigabit All-Optical Network Smart Neighborhood”, achieving full gigabit network coverage in Macau citywide. It enables a number of intelligent applications and drives the digital transformation of public services and urban governance, as well as exemplifying a sustainable, people-centric model of urban innovation. This “Smart City” project has garnered multiple prestigious awards both domestically and internationally, underscoring its contribution to the vision of “Digital Macau” and aligning with national strategies for technological advancement.With full-lifecycle AI service capabilities, CITIC Telecom is creating a robust innovation chain — from foundational infrastructure to advanced applications — to empower industries in their digital and intelligent transformation. This drives enterprises success in the global market.AI+ Connect: Fortifying Data Security and Compliance for a Trusted Digital WorldTechnology continues to accelerate global expansion for businesses, yet it also brings rising concerns over data protection and regulatory compliance. CITIC Telecom has established a comprehensive data security and compliance system for the AI era, aligning with China’s Data Security Law and Personal Information Protection Law, as well as international regulations such as the EU’s General Data Protection Regulation (GDPR) and ASEAN's Personal Data Protection Act (PDPA). With this forward-looking approach, the company has addressed key challenges such as cross-border data transmission, data protection, and financial risk control, providing end-to-end protection to build a trusted and intelligent digital world.To empower the future with intelligence, CITIC Telecom shared multiple lightweight AI+ applications that integrate the strengths of “Technology, Industry & Finance” during the “CITIC AI+ Practice Sharing” sessions, all tailored to empowering global enterprises.“Intelligent Financial Fraud Shield”: Financial Fraud, particularly in cross-border transactions, has become a pressing concern. CITIC Telecom’s “Intelligent Financial Fraud Shield” introduces multi-layered identity verification and real-time transaction monitoring to combat fraudulent behavior in cross-border transactions, effectively safeguarding assets for financial institutions and end users. This solution demonstrates the company’s innovative leadership in the digital finance area.“AI+ Connect: Cybersecurity Redefined with Precise Analysis”: CITIC Telecom has developed an all-round, multi-layered intelligent cybersecurity framework to enhance cyber defense. To effectively prevent external threats and data breaches, its AI Pentest simulates real-world attacks and scans for vulnerabilities, enabling proactive threat detection and remediation. Supported by three self-deployed, self-managed AI-driven Security Operations Centers (SOCs), the system constructs a robust and resilient defense that integrates machine learning, big data analytics and large model technologies for real-time threat monitoring and automated response. Meanwhile, the “AI Guardrail” spans from endpoint to transmission layers, guarding against unauthorized access and cross-border data leaks.“AI+ Connect: From Technology Empowerment to Data Empowerment”: Harnessing patented innovations, CITIC Telecom applies intelligent algorithms and big data analytics to help enterprises streamline data governance, integrate cross-system resources, and automate intelligent analytical reports. These capabilities also support diverse small-scale AI applications leveraging large model technologies, from data collection and monitoring to compliance reporting. Through a unified data platform, the company is reimagining enterprise-grade data governance architecture with cutting-edge technologies.Moving forward, CITIC Telecom remains committed to “Connecting the world” and advancing the “AI+ Connect” for enterprises. By leveraging the CITIC Group’s financial, technological and industrial synergies, the company will continue to deepen its AI investments, accelerating the transformation of applicable, manageable, and reliable technologies into real-world solutions. As global cooperation in the smart era grows, CITIC Telecom strives to be a pivotal bridge connecting China and the world, facilitating high-standard opening-up strategies and supporting Chinese enterprises expand globally.Visit Our Booth at H2-A308In this era of digital intelligence, technological innovation stands as the core driver of enterprise resilience and national progress. Embracing this spirit, CITIC Telecom is fast-tracking its technological roadmap to expand its global “Tech+” presence by integrating AI, big data, cloud computing and cybersecurity. We look forward to partnering with industry peers to ignite the future of intelligence and shape a world of shared success.For more details on “CITIC AI+ Practice Sharing”, please visit: https://mp.weixin.qq.com/s/svkprkpnnoC04gdsKZh9HAAbout CITIC Telecom International Holdings Limited (HKEx: 1883)CITIC Telecom International Holdings Limited was established in 1997 in Hong Kong, and was listed on the Hong Kong Stock Exchange on 3 April 2007. As one of the largest international telecommunications hubs in Asia Pacific, CITIC Telecom provides full-scale international telecommunications services to carrier clients around the globe, and integrated enterprise services in Southeast Asia through its wholly-owned subsidiary Acclivis Technologies and Solutions Pte. Ltd.CITIC Telecom International CPC Limited (“CPC”), CITIC Telecom’s wholly-owned subsidiary, provides end-to-end information and communications technology solutions to multinational corporate clients and business clients. CPC is one of the most trusted partners of these clients in the Asia-Pacific region, and provides a full range of ICT services to major enterprises and multinational corporate clients in Chinese mainland through its subsidiary China Enterprise ICT Solutions Limited.CITIC Telecom holds 99% equity interest in Companhia de Telecomunicações de Macau, S.A.R.L. (“CTM”). CTM is one of the leading integrated telecommunications services providers in Macau, and is the only full telecommunications services and ICT services provider in Macau. With a leading position in the market, CTM plays an important role in the ongoing development of Macau. CITIC Telecom has established branch organisations in 22 countries and regions, with approximately 2,500 staff and nearly 170 PoPs, and business serving 160 countries and regions, connecting to over 600 operators globally, and serving around 3,000 multinational corporations and 40,000 local companies around the globe.CITIC Group Corporation, a large multinational conglomerate headquartered in the People’s Republic of China, is the ultimate holding company of CITIC Telecom.For more information, please visit: www.citictel.comMedia Enquiry:CITIC TelecomMs. Sylvia LiTel: +852 3423 3168Email: sylviali@citictel.comCatherine YuenCITIC Telecom CPC (852) 2170 7536Email: catherine.yuen@citictel-cpc.com Copyright 2025 ACN Newswire via SeaPRwire.com.

HONG KONG, July 28, 2025 - (ACN Newswire via SeaPRwire.com) - Phoenitron Holdings Limited (“Phoenitron” or the “Company”, together with its subsidiaries, the “Group”; stock code: 8066) announced the grant of share options to 10 eligible employees (the “Grantees”) of its two wholly-owned subsidiaries, namely Shanxi Dongchuang Digital Entertainment Technology Group Company Limited (“Shanxi Dongchuang”) and CyberMirage (HK) Limited (“CyberMirage”). This initiative recognizes the significant contributions these employees have made in driving the Group’s sustained growth and exceptional performance. The grant of share options also further aligns employees’ interests with the Group’s long-term development goals, motivates them to actively participate in the Group's future growth, enhances overall competitiveness and operational performance, and strengthens their commitment and willingness to serve the Group in the long term.An aggregate of 52,500,000 share options were granted under the share option scheme, and each option entitles the grantee to subscribe for one share. The option exercise period is 10 years commencing from the date of grant. Worthy of notice is the exercise conditions for the share options granted are linked to the performance of Shanxi Dongchuang and CyberMirage. The unaudited aggregate profits before tax of the two companies for the nine months ending 30 September 2025 have to be not less than HK$75 million, reflecting the Group’s strong confidence in the future performance and ability to meet performance targets of the two subsidiaries.About Phoenitron Holdings LimitedThe mission of Phoenitron Holdings Limited is to provide shareholders with an optimum steam of steady income and gains by best leveraging the Company’s access to capital and unique investment opportunities. Phoenitron is comprised of three primary business segments, including smartcard manufacturing services, financial consulting and recycled resources investment. Its principal activities are manufacturing and sale of smart cards, provision of customised smart card application systems, provision of financial and management consultancy services, sale and trading of scrap metals and investment in the media and entertainment industry. Headquartered in Hong Kong, the Company has primary holdings and investment across Greater China. About Shanxi Dongchuang Digital Entertainment Technology Group Company LimitedShanxi Dongchuang Digital Entertainment Technology Group Company Limited (formerly known as “Hainan Dongchuang Digital Entertainment Technology Group Company Limited”) operates a pan-entertainment digital ecosystem membership e-commerce platform, which primarily provides entertainment e-commerce with private domain traffic, including the provision of digital products and services.About CyberMirage (HK) LimitedCyberMirage (HK) Limited (formerly known as "PMIS Limited") provides artificial intelligence voice services. Copyright 2025 ACN Newswire via SeaPRwire.com.

ANKARA, Turkey, July 28, 2025 - (ACN Newswire via SeaPRwire.com) - GEN Pharmaceuticals (GENIL.IS), Türkiye's leading specialty pharmaceutical company, announced positive results from its Phase 1 clinical trial evaluating the safety, tolerability, and pharmacokinetics (PK) of first-in-class and novel orally administered mitochondria-directed drug candidate SUL-238 in healthy elderly volunteers. The findings were presented at the Alzheimer's Association International Conference 2025 (AAIC®) in Toronto.This single oral ascending dose (SAD) Phase 1, first-in-human, randomized, double-blind, placebo-controlled study was conducted in three parts, involving a total of 53 healthy elderly adults. Part 1 included 6 cohorts (50, 100, 250, 500, 1000, and 2000 mg orally, n=23). In Part 2, the PK of a single 1000 mg oral dose was investigated in 10 healthy elderly adults. In Part 2B, the food effect was assessed using a randomized, single oral 2000 mg dose, two-treatment, two-period, crossover design (n=20).The trial results showed that single oral doses of 50-2000 mg of SUL-238 were safe and well-tolerated, while demonstrating a favourable PK profile and high cerebrospinal fluid (CSF) penetration. These findings make SUL-238 a promising candidate for further clinical development in neurodegenerative diseases, including Alzheimer's disease.No adverse effects (AEs) limited dose escalation, AE rates were comparable between SUL-238 and placebo, and all AEs were mild or moderate. The mean terminal elimination half-life was 0.86-3.80 hours, and the time to maximum plasma concentration was 0.50-1.39 hours. Under fed conditions, maximum plasma concentration (Cmax) and area under the plasma concentration-time curve (AUC0-∞) decreased by 50% and 60%, respectively. CSF-to-plasma percentages at 2 and 8 hours post-dose were 21.1% (±6.6%) and 74.2% (±46.0%).Abidin Gülmüs, Chairman of GEN, stated:"We are very encouraged by these promising first-in-human results, marking an important step forward in our mission to address the underlying biology of Alzheimer's disease."Nadir Ulu, MD, PhD, Vice President of R&D at GEN, added:"With its excellent safety and PK profile in this Phase 1 trial, combined with robust preclinical data, SUL-238 represents a strong candidate for further clinical development to meet the critical unmet needs in neurodegenerative diseases, including Alzheimer's disease."About SUL-238SUL-238 is a novel, first-in-class, hibernation-derived small molecule that targets mitochondria, the cell's "powerhouse." It supports mitochondrial bioenergetics via complex I/IV activation and has improved mitochondrial function in rodent models of neurodegenerative, cardiovascular, and renal diseases, as well as aging. SUL-238 crosses the blood-brain barrier and has undergone extensive safety evaluation in preclinical and Phase 1 studies. GEN licenses SUL-238 from Sulfateq BV for neurodegenerative disease applications.About GEN:Founded in 1998, GEN is Türkiye's leading specialty pharmaceutical company, focused on developing innovative therapies across multiple therapeutic areas. GEN manufactures high-quality, competitive products at its GMP-certified facility and pursues original drug development through two dedicated R&D centers and investments.About Sulfateq:Sulfateq B.V. is an early-stage Dutch biotech company that fosters strategic collaborations with academic and industrial research centers to accelerate the development of innovative new medicines. It has developed a novel class of small molecules, the SUL-compounds, that maintain mitochondrial health.For more information:www.genilac.com.trwww.sulfateqbv.comContact InformationBulutay GünesSr. Head of Corporate Brandb.gunes@genilac.comAli KetenciogluInvestor Relations Managera.ketencioglu@genilac.comKees van der GraafSulfateq CEOinfo@sulfateqbv.com Copyright 2025 ACN Newswire via SeaPRwire.com.

Vancouver, British Columbia--(ACN Newswire via SeaPRwire.com - July 28, 2025) - Doubleview Gold Corp (TSXV: DBG) (OTCQB: DBLVF) (WKN: LA1W038) (FSE: 1D4) ("Doubleview" or the "Company") is pleased to announce the commencement of an advanced exploration program at its 90%-owned copper-silver-zinc-gold Red Spring Project, located in central British Columbia, Canada. This initiative marks a significant step in unlocking the project's full potential and reinforces Doubleview's commitment to critical mineral development.Red Spring Project: Inaugural 3D IP Survey UnderwayThe Red Spring Project, a pillar in Doubleview's expanding portfolio, is situated in a highly prospective region of central British Columbia, Canada. The Company holds a 90% interest in this compelling copper-silver-zinc-gold project, which has demonstrated strong mineralization in historical drilling, particularly in its central zone. Decades of previous operator activities, including sampling, geophysical surveys, and approximately 4,000 feet of drilling, have laid the groundwork for Doubleview's current advanced exploration. The project is strategically important to the Company as it strengthens its emphasis on critical minerals.The first phase of Doubleview's 2025 exploration program at the Red Spring property comprises an inaugural 3D Induced Polarization (IP) survey. This state-of-the-art three-dimensional geophysical survey will target the Angus Zone, an area of high interest previously sampled and prospected by the Company. The survey is expected to be completed by the end of August 2025.The 3D IP survey will provide valuable insights into the subsurface geology and will contribute to planning and guiding future drill programs. Farshad Shirvani, President and CEO of Doubleview Gold Corp, commented: "Due to significant third-party interest in the Company's flagship HAT project, management is strategically advancing exploration at its Red Spring Project, as it has consistently demonstrated strong potential, both historically and through Doubleview's past exploration efforts. The 3D IP program will provide detailed information and valuable insights with minimal environmental impact. Our goal is to gain a better understanding of the deposit, expand the area of interest, and help define precise targets for further work, including drilling. The Red Spring Project is an important component in Doubleview's portfolio of properties and emphasizes our focus on critical minerals."Doubleview is dedicated to collaborative engagement with local stakeholders and First Nations and strives to apply sustainable exploration methods that ensure minimal land impact.Hat Polymetallic Deposit UpdateExploration and definition of Doubleview's flagship Hat Project continues with 2025 drilling surpassing 6,500 meters. Drill hole H099, currently in progress, is approaching the significant 100 drill hole milestone. The preliminary economic assessment (PEA), metallurgy, and environmental baseline studies are continuing and underscore the comprehensive advancement of this significant polymetallic deposit.About Doubleview Gold Corp With active programs at both the HAT and Red Spring projects, Doubleview anticipates that 2025 will be its most productive year to date, reflecting the Company's robust and exciting exploration and development activities.Doubleview Gold Corp, trading on the TSX-Venture Exchange (TSXV: DBG) (OTCQB: DBLVF) (WKN: LA1W038) (FSE: 1D4) is a Canadian-based mineral resource exploration and development company focused on the discovery and advancement of high-value mineral deposits in British Columbia. The Company controls a portfolio of prospective mineral properties, including the Hat polymetallic deposit and the Red Spring copper-gold-silver project.On behalf of the Board of Directors,Farshad Shirvani, President & Chief Executive Officer For further information please contact: Doubleview Gold Corp Vancouver, BC Farshad Shirvani President & CEO T: (604) 678-9587E: corporate@doubleview.caWebsite: www.doubleview.caNEITHER TSX VENTURE EXCHANGE NOR ITS REGULATION SERVICES PROVIDER (AS THAT TERM IS DEFINED IN THE POLICIES OF THE TSX VENTURE EXCHANGE) ACCEPTS RESPONSIBILITY FOR THE ADEQUACY OR ACCURACY OF THIS RELEASE.Certain of the statements made and information contained herein may constitute "forward-looking information". In particular references to the private placement and future work programs or expectations on the quality or results of such work programs are subject to risks associated with operations on the property, exploration activity generally, equipment limitations and availability, as well as other risks that we may not be currently aware of. Accordingly, readers are advised not to place undue reliance on forward-looking information. Except as required under applicable securities legislation, the Company undertakes no obligation to publicly update or revise forward-looking information, whether as a result of new information, future events or otherwise.To view the source version of this press release, please visit https://www.newsfilecorp.com/release/260280 Copyright 2025 ACN Newswire via SeaPRwire.com.

Tokyo, Japan, July 28, 2025 - (ACN Newswire via SeaPRwire.com) - Quantum Solutions Co., Ltd. (2338.T) and its affiliates (the “Quantum Solutions’ Group” or “Quantum Solutions”), a Tokyo Stock Exchange-listed company, today announced a new strategic milestone in its digital asset initiative. The Quantum Solutions’ Group, has entered into a business collaboration arrangement with TDX Strategies Ltd, a renowned digital asset technology company in Asia. The two parties will cooperate extensively in areas including Bitcoin trade execution, asset custody, structured product design, and market risk management—offering end-to-end technical and service support for Quantum Solutions’ Bitcoin Treasury strategy.Quantum Solutions previously disclosed its plan to accumulate up to 3,000 Bitcoins over the next 12 months, aiming to hedge inflation risks, optimize asset structure, and enhance the agility of its financial system. The collaboration with TDX Strategies marks a key transition from capital planning to systemized execution and is expected to substantially strengthen the Quantum Solutions’ technical capabilities and operational security in the management of digital assets.TDX Strategies is a tech-driven enterprise focused on trading and structuring of digital financial products. It holds licensed investment trading and operational status in the British Virgin Islands (BVI). With a strong track record in blockchain asset operations and a robust institutional network across markets, TDX serves a range of Asian family offices, asset managers, and corporate clients. For this collaboration, Quantum Solutions’ Group agrees to prioritize the selection of TDX’s paid cryptocurrency services on a non-exclusive basis, ensuring operational flexibility and execution reliability for the Treasury business.According to the agreement, TDX Strategies will provide comprehensive support to Quantum Solutions’ BTC Treasury business, including: assisting in the development of an institutional-grade trade execution system tailored for Bitcoin; establishing enterprise-level cold/hot wallet management frameworks and multi-signature security protocols to safeguard custody; designing principal-protected and yield-enhancing structured products based on Bitcoin holdings to improve capital efficiency; and delivering ongoing consulting in operational, technical, risk exposure control, and market response strategies.TDX Strategies is recognized as a next-generation digital asset firm with hands-on expertise in structured finance instruments, institutional trading infrastructure, and cross-chain solutions. Its team combines deep knowledge in blockchain application development and traditional risk management, and the company enjoys a strong reputation in the Asian crypto-financial space. Notably, TDX is one of the portfolio companies under a strategic partner of Quantum Solutions Mr. Tak Cheung Yam, the ultimate beneficial majority shareholder of renowned American media Forbes Media LLC a .Mr. Yam is also the sole owner of Integrated Asset Management (Asia) Limited, which recently extended a USD 10 million loan to Quantum Solutions’ Group to support the initial phase of its Bitcoin Treasury initiative. As a globally respected investor, Mr. Yam has committed both capital and infrastructure to accelerate Quantum Solutions’ entry into the digital asset space. Through this partnership, TDX Strategies’ technological resources and professional team have also been made available to Quantum Solutions, reflecting Mr. Yam’s full-spectrum commitment—both financially and operationally.Quantum Solutions noted that the collaboration establishes a comprehensive support system for its digital asset strategy—spanning funding, infrastructure, and compliance. This creates a closed-loop model from capital infusion to asset management, and represents a clear shift from “reserve asset” to “strategic asset” status for Bitcoin within the company’s evolving financial framework. The initiative is designed to deepen the asset’s integration into the corporate finance structure while maximizing its intrinsic and strategic value.Looking ahead, Quantum Solutions and TDX intend to expand their collaboration to cover a wider range of use cases, including Bitcoin yield strategies, stablecoin allocations, and cross-chain structured product development. These efforts aim to further enhance the flexibility and compounded value potential of the company’s digital asset portfolio.This partnership marks not only the operational execution of the company’s digital asset strategy, but also a significant step forward in building a future-ready financial architecture. As the Bitcoin Treasury program advances, Quantum Solutions expects to accelerate the development of an enterprise-grade reserve framework that is institutionalized, auditable, and responsive to market conditions—providing robust safeguards for long-term asset security and corporate growth.About Quantum Solutions Co., Ltd.Quantum Solutions Co., Ltd. (Tokyo Stock Exchange: 2338.T) is a Tokyo-based high-growth technology company specializing in artificial intelligence, big data analytics, and blockchain-related innovation. Founded in 2004 and listed on the Tokyo Stock Exchange, the company delivers advanced technology solutions across a range of industries, including fintech, healthcare, and smart manufacturing. In its financial year ended 28 February 2025, Quantum Solutions reported approximately USD 4.7 million in revenue and is currently holdings over several trademarks and patents in games. For more information, please visit: https://www.quantum-s.co.jp/en/corporateForward-Looking StatementsThis press release contains forward-looking statements based on information currently available to the company and certain assumptions regarding future events and expectations. These statements are subject to various risks and uncertainties—including but not limited to changes in policy, market conditions, technological developments, and regulatory factors—that could cause actual results to differ materially from those expressed or implied in such statements. Existing and prospective investors are advised to consider potential risks carefully and not to place undue reliance on any forward-looking statements contained herein. Such statements speak only as of the date of this release. Unless required by law, the company undertakes no obligation to update or revise any forward-looking statements in light of new information, future events, or other circumstances.For further enquiries, please contact:Hong Kong/International:Mr. Steven TungEmail: steven.tung@quantum-s.co.jpJapan:Ms. Linda PengEmail: linda.peng@quantum-s.co.jp Copyright 2025 ACN Newswire via SeaPRwire.com.

香港，2025年7月28日 - (亚太商讯 via SeaPRwire.com) - 小黄鸭德盈控股国际有限公司（及其下属公司合称为「小黄鸭德盈」或「集团」，股份代号：2250）公布截至2025年6月30日止六个月（「期内」或「上半年」）盈利预告。期内，受益于集团角色授权业务的授权金收入显著增长、设计咨询服务费增加，以及电子商务及其他业务收入因持续于电商平台开展推广工作而扩展等，预期集团整体业绩改善。就集团上半年未经审核综合管理账目所作的初步评估（不包括合约资产、金融资产减值及公允值变动），预期小黄鸭德盈期内收入较上年的5,992万港元同比大幅增长不低于30%。同时，经营亏损亦较上年大幅收窄不少于30%。小黄鸭德盈近年持续以创新驱动IP生态发展及系统协同，透过「IP+全产业链」的前瞻性布局，推动集团业务发展和全球化布局加速。未来，小黄鸭德盈将继续创新商业模式，强化IP生态系统的协同效应，致力实现品牌价值与商业价值的长期稳健发展与共赢成长。关于小黄鸭德盈控股国际有限公司小黄鸭德盈控股国际有限公司是一家主要从事角色知识产权业务的投资控股公司。集团自 2005 年创立明星 IP「B.Duck 小黄鸭」以来，在 IP 各类授权及运营上拥有丰富经验。集团着力于 IP 实景文旅、游戏文娱、商品零售、跨境出海等业务增长点，实现IP授权、商品企划、供应链、销售渠道等业务板块的优化整合，小黄鸭德盈不断深化 IP 商业化生态圈建设，致力打造 B.Duck 成为「全球快乐符号」，推动「Make A Playful World」的使命落地。 Copyright 2025 亚太商讯 via SeaPRwire.com.

香港，2025年7月28日 - (亚太商讯 via SeaPRwire.com) - 日本东京证券交易所挂牌企业 Quantum Solutions Co., Ltd. （东京证券交易所上市编号：2338）及其关联公司（「Quantum Solutions集团」或「Quantum Solutions」）今日进一步公布集团在数字资产领域的战略部署，并与亚洲知名数字资产科技公司 TDX Strategies Ltd 签署业务合作协议。双方将于比特币交易执行、资产托管、结构化产品设计以及市场风险管理等方面展开全面合作，为 Quantum Solutions 的比特币储备计划提供一站式技术与服务支持。Quantum Solutions 早前已公布，将于未来12个月内逐步建仓最多3,000枚比特币，以对冲通胀风险、优化资产结构并提升财务系统的灵活性。本次与 TDX Strategies 的合作，标志着相关业务从资本层面正式迈入系统化执行阶段，合作框架的落地有望全面强化Quantum Solutions于数字资产运作方面的专业能力与风控保障。TDX Strategies 是一家专门从事数字结构化产品交易服务的科技型企业，在英属处女群岛（BVI）合法持有投资交易与营运许可。该公司拥有丰富的区块链资产操作经验与跨市场机构资源网络，并与多家亚洲家族办公室、资产管理机构及企业建立了长期合作。根据本次合作，Quantum Solutions 同意于未来24个月内非独家形式优先考虑订阅TDX 提供的加密货币服务、，以保障储备业务的灵活性与稳定性。根据协议，TDX Strategies 将为 Quantum Solutions 的比特币业务提供多层次支持，包括：协助构建比特币交易与执行机制，以实现不同市场条件下的最优采购策略；建立符合企业级标准的冷／热钱包管理系统与多重签名安全架构，保障数字资产的托管与操作安全；根据持仓比特币设计具备本金保障与收益增值潜力的结构化产品，提升资产使用效率；同时亦将于营运、技术、风险敞口控管、市场波动应对等领域提供持续的技术咨询与策略建议。TDX Strategies 为一间科创型数字资产公司，在结构化金融工具、机构化交易系统、跨链资产解决方案方面具备实操经验，技术团队专长横跨区块链应用与传统风控体系，于亚洲加密金融圈建立稳固声誉。值得一提的是，TDX 属 Quantum Solutions 的战略合作方，美国著名财经媒体 福布斯Forbes Media LLC幕后东主任德章先生集团旗下。任德章先生同时亦为 Integrated Asset Management (Asia) Limited 的全资拥有人。该机构早前已向 Quantum Solutions 集团 提供 1,000 万美元贷款，用以启动比特币储备计划的首阶段资金投入。作为国际知名投资人，任先生不仅出资推动公司进军数字资产领域，亦开放其科技资产平台 TDX Strategies 的应用权限与专业团队予Quantum Solutions采用，实现全方位支持。Quantum Solutions 表示，是次合作为公司数字资产业务建立起涵盖资金来源、技术执行与合规管控的完整支撑体系，构成从资本动员到资产运营的闭环模式。此举进一步体现公司将比特币由「储备性资产」升级为「战略性资产」的财务策略转型方向，并强化其于企业财务架构中的核心地位与潜在价值。未来，Quantum Solutions 与 TDX 将持续拓展合作范围，探索更多场景应用，包括但不限于比特币收益管理、稳定币配置与跨链结构化产品设计，提升数字资产的灵活性与多元增值能力。本次合作不仅是数字资产业务的具体落实，更象征 Quantum Solutions 正积极构建面向未来的财务战略框架。随着比特币储备计划的持续推进，公司预期将加速建立具制度化、审计能力与市场反应效率的企业级数字资产储备体系，为中长期资产安全与企业成长提供双重保障。关于 Quantum SolutionsQuantum Solutions Co.,Ltd.（东京证券交易所：2338.T）是一家总部位于日本东京的高成长科技企业，专注于人工智能、大数据分析及区块链相关技术的研发与应用。公司成立于2004年，并于东京证券交易所挂牌上市。Quantum Solutions 的核心业务涵盖金融科技、医疗健康、智能制造等多个行业领域，致力于以技术驱动产业转型。截至 2025 年 2 月 28 日，公司实现收入约470 万美元，拥有数项游戏类别的注册商标和技术专利。更多信息请访问公司官网：https://www.quantum-s.co.jp/en/corporate前瞻性声明本新闻稿包含根据公司目前可取得之资讯，以及对未来事件与预期所作的若干假设所形成的前瞻性声明。此类声明涉及各种风险与不确定性，包括但不限于政策变动、市场状况、技术发展及监管因素，皆可能导致实际结果与此类声明中所表达或暗示的结果出现重大差异。建议现有及潜在投资者审慎评估潜在风险，并避免对本新闻稿中所包含的任何前瞻性声明寄予过高信赖。此类声明仅适用于本新闻稿发布之日，除法律另有规定外，公司并无义务因新资讯、未来事件或其他情况而更新或修正任何前瞻性声明。如有进一步查询，请联络：香港/国际：Mr. Steven TungEmail: steven.tung@quantum-s.co.jp日本：Ms. Linda PengEmail: linda.peng@quantum-s.co.jp Copyright 2025 亚太商讯 via SeaPRwire.com.

土耳其安卡拉, 2025年7月29日 - (亚太商讯 via SeaPRwire.com) - GEN制药公司（GENIL.IS）是土耳其领先的专业制药公司，日前宣布其第一阶段临床试验取得积极结果。该试验旨在评估首创且新型的口服线粒体靶向候选药物 SUL-238 在健康老年志愿者中的安全性、耐受性以及药代动力学（PK）表现。研究结果已在2025年阿尔茨海默病协会国际会议（AAIC®）上于多伦多公布。本次第一阶段临床试验为首个人体试验，采用单次口服递增剂量（SAD）设计，随机、双盲、安慰剂对照，共分为三个部分，纳入了共计53名健康老年志愿者。第一部分包括6个剂量组（口服剂量分别为50、100、250、500、1000和2000毫克，n=23）。第二部分中，研究了单剂1000毫克口服剂量在10名健康老年人的药代动力学特征。第二部分B评估了食物的影响，采用随机、单剂2000毫克口服、双处理、双周期交叉设计（n=20）。试验结果显示，50至2000毫克的单次口服剂量 SUL-238 在受试者中均表现出良好的安全性和耐受性，同时具备良好的药代动力学特征，并能较好地渗透至脑脊液（CSF）。这些结果使得 SUL-238 成为治疗包括阿尔茨海默病在内的神经退行性疾病的有前景的临床开发候选药物。未观察到任何不良反应（AEs）限制剂量递增，SUL-238组与安慰剂组的不良事件发生率相当，且所有不良事件均为轻度或中度。平均终末消除半衰期为0.86至3.80小时，达峰时间为0.50至1.39小时。在进食状态下，血浆药物最大浓度（Cmax）和血浆浓度-时间曲线下面积(AUC0-∞) 分别下降了50%和60%。给药后2小时和8小时脑脊液与血浆的浓度比例分别为21.1%（±6.6%）和74.2%（±46.0%）。GEN董事长 Abidin Gülmüş 表示：“这些令人鼓舞的首次人体试验结果为我们带来了极大信心，标志着我们在应对阿尔茨海默病潜在生物机制方面迈出了重要一步。”GEN研发副总裁、医学博士兼博士 Nadir Ulu 补充道：“在本次第一阶段试验中，SUL-238 展现出优异的安全性和药代动力学特征，结合扎实的临床前数据，使其成为未来临床开发的有力候选药物，有望满足包括阿尔茨海默病在内的神经退行性疾病领域亟待解决的临床需求。”关于 SUL-238SUL-238 是一种首创的新型小分子药物，其源自冬眠机制，靶向细胞的“能量工厂”——线粒体。该药物通过激活线粒体复合体 I 和 IV 来支持线粒体的生物能量代谢，并已在神经退行性疾病、心血管疾病、肾脏疾病及衰老的啮齿动物模型中显著改善线粒体功能。SUL-238 能穿越血脑屏障，并已在临床前研究和第一阶段试验中完成了广泛的安全性评估。GEN 获得了 Sulfateq BV 授权，可将 SUL-238 应用于神经退行性疾病的治疗开发。关于 GENGEN 成立于1998年，是土耳其领先的专业制药公司，致力于在多个治疗领域开发创新疗法。GEN 拥有符合 GMP 认证标准的生产设施，生产高质量且具市场竞争力的药品，并通过两个专属研发中心及研发投资推动原创药物开发。关于 SulfateqSulfateq B.V. 是一家位于荷兰的早期生物技术公司，致力于与学术界和工业研究中心开展战略合作，以加速创新药物的开发。该公司开发了一类新型小分子化合物——SUL 系列药物，旨在维持线粒体健康功能。欲了解更多信息:www.genilac.com.trwww.sulfateqbv.com联系信息Bulutay GünesSr. Head of Corporate Brandb.gunes@genilac.comAli KetenciogluInvestor Relations Managera.ketencioglu@genilac.comKees van der GraafSulfateq CEOinfo@sulfateqbv.com Copyright 2025 亚太商讯 via SeaPRwire.com.

SHENZHEN, CHINA, July 29, 2025 - (ACN Newswire via SeaPRwire.com) - China Medical System Holdings Limited (“CMS” or the “Group”) is pleased to announce that on 28 July 2025, the New Drug Application (NDA) for improved new drug ZUNVEYL (Benzgalantamine Gluconate Enteric-coated Tablets) (“ZUNVEYL” or the “Product”) has been accepted by the National Medical Products Administration of China (NMPA). The Product is indicated for the treatment of mild-to-moderate dementia of the Alzheimer’s type in adults.About Product ZUNVEYLZUNVEYL was approved in July 2024 by the U.S. Food and Drug Administration (FDA) for the treatment of mild-to-moderate dementia of the Alzheimer’s type in adults. As a new generation of acetylcholinesterase inhibitor (AChEI), ZUNVEYL can inhibit the acetylcholinesterase from breaking down the neurotransmitter acetylcholine, increase the level of acetylcholine in the central nervous system, and therefore alleviate cognition and memory impairment in Alzheimer’s disease patients. As a prodrug of galantamine, ZUNVEYL remains inert as it passes through the stomach and the intestine, and eventually releases the active drug into the bloodstream after being metabolized by the liver. With such a mechanism of action, ZUNVEYL is expected to have equivalent efficacy as galantamine with the potential of reducing gastrointestinal (GI) side effects and addressing certain tolerability issues. Galantamine has accumulated extensive evidence of efficacy and demonstrated long-term clinical benefit in the treatment of mild-to-moderate dementia of the Alzheimer’s type since the approval of FDA in 2001[1]. Moreover, GI adverse events documented across all studies for ZUNVEYL were less than 2% and no insomnia was observed[2]. As the second oral therapy approved by FDA for the treatment of Alzheimer’s disease during the past decade, ZUNVEYL demonstrates a potentially better gastrointestinal safety profile to improve compliance of Alzheimer’s disease patients and therefore brings clinical benefits. Patent in regard to use of ZUNVEYL has already been granted in China.About Alzheimer’s DiseaseAlzheimer’s disease is a chronic, progressive neurodegenerative disease characterized by progressive decline in memory and other cognitive functions, among which some of the patients will progress to dementia. Dementia is a kind of syndrome with acquired cognitive function impairment as the core symptom, and can lead to the reduction of patients’ daily living, learning, working and social interaction ability. Alzheimer dementia accounts for 50% to 70% of all types of dementia[3,4]. According to the epidemiological study results published in the Lancet Public Health[5], there are about 9.83 million patients with Alzheimer dementia in China, of which 7.93 million are mild-to-moderate[6]. With the intensifying aging trend, the number of patients and the consequent disease burden will further increase in the future.Currently the clinical treatment of Alzheimer’s disease can be categorized as improving cognitive symptoms and decelerating disease progression[7], and AChEI belongs to the former. According to the Research Report on the Diagnosis and Treatment of Alzheimer’s disease Patients in China[8], the high incidence of side effects is one of the major pain points for existing drugs for Alzheimer’s disease, and drug intolerance is one of the challenges in current treatment of Alzheimer’s disease. Tolerability affects therapy adherence, with data showing that 55% of Alzheimer’s disease patients discontinue their medication after one year, mainly due to GI side effects and insomnia. Medication discontinuation can cause risk to patients themselves, and dissatisfaction and burden among patient’s family, physicians, and caregivers[9]. Therefore, Alzheimer’s disease patients still have an urgent need for safer therapies.On 8 January 2025, the Group through a wholly-owned subsidiary of the Company entered into a License, Collaboration and Distribution Agreement (the “Agreement”) with Alpha Cognition Inc. (“Alpha”) of the improved new drug ZUNVEYL for the treatment of mild-to-moderate dementia of the Alzheimer’s type. In accordance with the Agreement, the Group is entitled to an exclusive right to develop, register, manufacture, import, export and commercialize the Product in Asia (excluding Japan and the Middle East region), Australia and New Zealand (the “Territory”), Alpha reserves the right to manufacture and supply in the Territory. The term of cooperation commences on the effective date of the Agreement and extends for twenty years (the “Initial Term”), it may be automatically renewed every five years upon the expiration of the Initial Term unless terminated by notice from either party.Around six months after obtaining the above rights of ZUNVEYL, the Group promptly submitted the NDA in China, demonstrating its efficient allocation of resources and robust capabilities in registration promotion. ZUNVEYL will further diversify the Group’s innovative drug product matrix and enhance the Group’s comprehensive competitiveness. The Product will synergize with the Group’s various central nervous system products including the innovative drug VALTOCO (diazepam nasal spray) and the original brand drug Deanxit (flupentixol and melitracen tablets) on sale and the innovative drug Y-3 for Injection under development in terms of expert network and market resources. Relying on the Group’s successful commercialization experience and compliant and efficient commercialization system, if ZUNVEYL is approved for marketing, it will bring a new drug option for the treatment of cognitive impairment in Chinese Alzheimer’s disease patients, meeting the clinical need for drugs of both efficacy and safety, improving disease diagnosis and treatment practices, thereby benefiting patients. The Product is expected to have a positive impact on the Group’s financial results.Reference:1. Xu, Hong et al. Long-term Effects of Cholinesterase Inhibitors on Cognitive Decline and Mortality. Neurology vol. 96,17 (2021): e2220-e2230. doi:10.1212/WNL.00000000000118322. Safety profile of ZUNVEYL as disclosed by Alpha: https://www.alphacognition.com/investors/news/alpha-cognitions-oral-therapy-zunveyl-receives-fda-approval-to-treat-alzheimers-disease- 3. 2018 Chinese Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Impairment (Chapter 1): Dementia Classification and Diagnostic Criteria [J]. National Medical Journal of China, 2018, 98 (13): 965-970. DOI: 10.3760/cma.j.issn.0376-2491.2018.13.0034. 2018 Chinese Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Impairment (Chapter 2): Guidelines For Diagnosis and Treatment of Alzheimer's Disease [J]. National Medical Journal of China, 2018,98 (13): 971-977. DOI: 10.3760/cma.j.issn.0376-2491.2018.13.0045. Jia, Longfei et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study. The Lancet. Public health vol. 5,12 (2020): e661-e671. doi:10.1016/S2468-2667(20)30185-76. Yuan, Jing et al. Severity Distribution of Alzheimer’s Disease Dementia and Mild Cognitive Impairment in the Framingham Heart Study. 1 Jan. 2021: 807-817.7. Mayo Clinic. 2024. Alzheimer’s Disease: Therapies to Improve Cognitive Symptoms and Decelerate Disease Progression. https://www.mayoclinic.org/zh-hans/diseases-conditions/alzheimers-disease/in-depth/alzheimers/art-200481038. Research Report on the Diagnosis and Treatment of Alzheimer’s Disease Patients in China (2020). Alzheimer's Disease Chinese (ADC). https://www.adc.org.cn/index.php/book/chinaadzlxzbg2020/chinaadzlxzbg2020-381.html9. Data on patient discontinuation as disclosed by Alpha: https://www.alphacognition.com/investors/news/alpha-cognitions-oral-therapy-zunveyl-receives-fda-approval-to-treat-alzheimers-disease-About CMSCMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. 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